dihydrodipicolinate reductase (NADPH)
function
biosynthesis of lysine and peptidoglycan
product
dihydrodipicolinate reductase (NADPH)
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.1|Biosynthesis of peptidoglycan][category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.6|Biosynthesis/ acquisition of lysine/ threonine][category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.1|Biosynthesis of cell wall components] → [category|SW 2.6.1.1|Biosynthesis of peptidoglycan][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][SW|Categories] containing this gene/protein
[SW|cell wall synthesis], [SW|biosynthesis/ acquisition of amino acids], [SW|Biosynthesis of cell wall components], [SW|essential genes]This gene is a member of the following [SW|regulons]
[SW|Spx regulon]Gene
Phenotypes of a mutant
essential [Pubmed|12682299]The protein
Catalyzed reaction/ biological activity
2,3,4,5-tetrahydrodipicolinate + NADP+ = 2,3-dihydrodipicolinate + NADPH (according to Swiss-Prot)Protein family
glucose-6-phosphate dehydrogenase family (according to Swiss-Prot)[SW|Cofactors]
NADP+Structure
[PDB|1YL6] (from ''Mycobacterium tuberculosis'', 46% identity, 67% similarity) [Pubmed|20057050][SW|Interactions]
forms tetramers [Pubmed|24261876]Expression and Regulation
Operon
''[protein|search|ypjD]-[protein|search|dapB]-[protein|search|mgsA]-[SW|bshB1]-[protein|search|bshA]-[protein|search|cca]-[protein|search|birA]'' [Pubmed|20308541][SW|Sigma factor]
[protein|search|SigA] [Pubmed|23894131]Regulation
induced by diamide stess (thiol depletion) ([protein|search|Spx]) [Pubmed|23894131]Regulatory mechanism
[protein|search|Spx]: transcription activation [Pubmed|23894131]References
