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prfA [Mon Jan 18 2016 18:48:02 GMT+0100 (CET)]
peptide chain release factor 1
product
peptide chain release factor 1
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.11|Translation factors][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][SW|Categories] containing this gene/protein
[SW|translation], [SW|essential genes]Gene
Coordinates on the chromosome (coding sequence)
3,797,085 -> 3,798,155
Phenotypes of a mutant
essential [Pubmed|12682299]The protein
Catalyzed reaction/ biological activity
binds to the ribosome through specific recognition of messenger RNA stop codons and triggers hydrolysis of the bond between the nascent polypeptide and the transfer RNA at the peptidyl-tRNA site, thereby releasing the newly synthesized protein. PrfA is highly specific for a U in the first stop-codon position and recognizes UAA and UAGProtein family
prokaryotic/mitochondrial release factor family (according to Swiss-Prot)[SW|Localization]
cytoplasm (according to Swiss-Prot)References
12237459,20512119,25217634