ecsA [2017-8-11 16:0:3]

ABC transporter (ATP-binding protein), mutation affects proteolysis by RasP (no processing of RsiW and FtsL)

locus: BSU10040

pI: 5.64

mw: 27.57 kDa

protein length: 247 aa

gene length: 741 bp

function: regulation of the secretion apparatus and of intra-membrane proteolysis

product: ABC transporter (ATP-binding protein)

essential: no

synonyms: prsT, ecs-26, yhaD

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.3|Regulatory ABC transporters]
• [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.5|Protein secretion]
• [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.1|Sigma factors and their control] → [category|SW 3.4.1.2|Control of sigma factors]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

Gene

Coordinates: 1,077,440 → 1,078,183

Phenotypes of a mutant

• no processing of [protein|4E720917045032E8B45CB8AF6E5C13AE0E48EE33|RsiW] and [protein|79712F4CF884A660C71B45B3397AEFA5C0AFA683|FtsL] [Pubmed|18599827]
• inactivation of ''[gene|59A7B26F810D7FEB07C176A8B2ECF6B83803DE49|ecsA]'' reduces sporulation efficiency to 0.1% that of wild type cells [Pubmed|26735940]

The protein

Protein family

• [SW|ABC transporter] domain (according to Swiss-Prot)

[SW|Localization]

• membrane associated (via [protein|665BE3614B466067D64D1FB275ECDDE12CBFC9D4|EcsB]) [Pubmed|10092453]

Expression and Regulation

Operons

• genes: [gene|59A7B26F810D7FEB07C176A8B2ECF6B83803DE49|ecsA]-[gene|665BE3614B466067D64D1FB275ECDDE12CBFC9D4|ecsB]-[gene|6D07C98A82C8960133BC50E40EF5D56A21071316|ecsC]
  description: [pubmed|22383849]

References

• 8581172,12884008,10092453,18599827,10027970,26735940