phosphodiesterase/alkaline phosphatase, degrades wall teichoic acid during phosphate starvation
function
aquisition of phosphate upon phosphoate starvation, degradation of wall teichoic acid during phosphate starvation
product
phosphodiesterase/alkaline phosphatase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.3|Phosphate metabolism][category|SW 6|Groups of genes] → [category|SW 6.12|Secreted proteins][SW|Categories] containing this gene/protein
[SW|phosphate metabolism]This gene is a member of the following [SW|regulons]
[SW|PhoP regulon]Gene
Coordinates on the chromosome (coding sequence)
284,011 -> 285,762
The protein
Catalyzed reaction/ biological activity
endohydrolytic activity on wall teichoic acid, acts in concert with [SW|GlpQ] [Pubmed|27780866]A phosphate monoester H2O = an alcohol phosphate (according to Swiss-Prot) [SW|Cofactors]
one Fe3 and two Ca2 [Pubmed|25217636] Structure
[PDB|2YEQ] [Pubmed|25217636][SW|Localization]
extracellular (signal peptide) [Pubmed|18957862], secreted by the [SW|TatAD]-[SW|TatCD] complex [Pubmed|19395490][SW|Interactions]
[SW|TatAD]-[protein|search|PhoD] [Pubmed|12867413]Expression and Regulation
Operon
''[protein|search|phoD]-[SW|tatAD]-[SW|tatCD]'' [Pubmed|22383849][SW|Sigma factor]
[protein|search|SigA] [Pubmed|10094677]Regulation
expressed under conditions of phosphate limitation ([protein|search|PhoP]) [Pubmed|10094677]Regulatory mechanism
[protein|search|PhoP]: transcription activation [Pubmed|10094677]Additional information
expression of the operon depends on functional [protein|search|HemAT] and [protein|search|CsbC] [PubMed|23180473]Labs working on this gene/protein
[SW|Oscar Kuipers], University of Groningen, The Netherlands[http://molgen.biol.rug.nl/molgen/index.php Homepage]References
Reviews
Original publications
8760916,10913081,12867413,10094677,12218047,10556724,19180538,10094677,18957862,19383693,19395490,22960285,22383849,23180473,25217636,25666134,27118079,27780866 
