protein component of RNase P, metal-dependent 5 end maturation of precursor tRNAs
function
cleavage of precursor sequences
from the 5 ends of pre-tRNAs
product
protein component of RNase P (substrate specificity)
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.2|RNA synthesis and degradation] → [category|SW 3.2.4|RNases] → [category|SW 3.2.4.2|Endoribonucleases][category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.8|tRNA modification and maturation][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][SW|Categories] containing this gene/protein
[SW|RNAses], [SW|translation], [SW|essential genes]Gene
Coordinates on the chromosome (coding sequence)
4,214,753 -> 4,215,103
Phenotypes of a mutant
essential [Pubmed|12682299]The protein
Catalyzed reaction/ biological activity
Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from [protein|search|tRNA] precursor (according to Swiss-Prot)5' end maturation of tmRNA [Pubmed|25402410]Protein family
rnpA family (according to Swiss-Prot)[SW|Domains]
RNR motif: residues 60-68, stabilizes complexes with both the RNA part of [SW|RNase] P (''[protein|search|rnpB]'') and with pre-[protein|search|tRNA] ([protein|search|rnpB]-[protein|search|RnpA]-pre-[protein|search|tRNA]) [Pubmed|21622899]Structure
[PDB|1A6F] [Pubmed|9563955][PDB|3Q1R] (complex of RnpA with the RNA [protein|search|RnpB] and [protein|search|tRNA], from ''Thermotoga maritima'') [Pubmed|21076397][SW|Interactions]
forms dimers [Pubmed|21764917][protein|search|RnpA]-[protein|search|RpmH][protein|search|RnpA]-[protein|search|RnpB] [Pubmed|21622899][protein|search|RnpA]-[protein|search|CshA] [Pubmed|21764917]Expression and Regulation
Regulation
expression transiently increases in the forespore [Pubmed|22848659]Labs working on this gene/protein
[SW|Carol Fierke], University of Michigan, Ann Arbor, USA [https://www.chem.lsa.umich.edu/chem/faculty/facultyDetail.php?Uniqname=fierke homepage][SW|Roland Hartmann], Marburg University, Germany [http://www.pharmazie.uni-marburg.de/pharmchem/akhartmann/ag_hartmann.htm homepage]References
Reviews
19215776,8901495,17868095,14691942,16650980,16980936,16679018,14550630 Original Publications
10390342,17919279,17355991,11812129,16980484,11454206,19549719,11454206,9563955,19932118,17299131,20476778,11258888,16185070,21764917,22848659,21076397,20843005,21622899,24364358,25249623,25402410,26267651 
