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manP [Tue Dec 13 2016 11:16:32 GMT+0100 (CET)]
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manP [Tue Dec 13 2016 11:16:32 GMT+0100 (CET)]

trigger enzyme: mannose-specific phosphotransferase system, EIIBCA of the PTS
locus
BSU12010
pI
6.72
mw
61.00 kDa
function
mannose uptake and phosphorylation, control of ManR activity
product
trigger enzyme: mannose-specific phosphotransferase system, EIIBCA
essential
no
synonyms
yjdD

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.2|Phosphotransferase system] → [category|SW 1.2.2.2|Sugar specific PTS proteins]
  • [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.9|Utilization of mannose]
  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.4|Control of PRD-type regulators]
  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.3|Trigger enzyme] → [category|SW 3.4.3.1|Trigger enzymes of the PTS that control the activity of PRD-containing transcription factors]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.3|Phosphorylation on a Cys residue]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.4|Phosphorylation on a His residue]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.5|Phosphorylation on a Ser residue]
  • [SW|Categories] containing this gene/protein

  • [SW|phosphotransferase systems], [SW|utilization of specific carbon sources], [SW|transcription factors and their control], [SW|trigger enzyme], [SW|membrane proteins], [SW|phosphoproteins]
  • This gene is a member of the following [SW|regulons]

  • [SW|ManR regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    1,272,725 -> 1,274,677

    The protein

    Catalyzed reaction/ biological activity

  • transport and concomitant phosphorylation of mannose
  • Protein family

  • [SW|PTS] permease, fructose/ mannitol permease (Fru) family [Pubmed|10627040]
  • Paralogous protein(s)

  • [protein|search|FruA]
  • Modification

  • phosphorylation on Ser-365 [Pubmed|17218307]
  • Structure

  • [PDB|2R48] (IIB domain)
  • [SW|Localization]

  • membrane
  • [SW|Interactions]

  • [protein|search|ManP]-[protein|search|ManR], [protein|search|ManP]-[PtsH|search|HPr]
  • Expression and Regulation

    Operon

  • ''[protein|search|manP]-[protein|search|manA]-[protein|search|yjdF]'' [Pubmed|20139185]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|20139185]
  • Regulation

  • induced by mannose ([protein|search|ManR]) [Pubmed|20139185]
  • repressed by glucose ([protein|search|ManR]) [Pubmed|20139185]
  • strongly induced in response to glucose starvation in M9 medium [Pubmed|23033921]
  • Regulatory mechanism

  • [protein|search|ManR]: transcription activation in the presence of mannose and absence of glucose [Pubmed|20139185]
  • References

  • 10627040,17218307,10627040,20139185,23033921,23551403,26238998