argH [Mon Aug 31 2015 13:56:14 GMT+0200 (CEST)]

argininosuccinate lyase

locus: BSU29440

pI: 4.86

mw: 51.00 kDa

function: biosynthesis of arginine

product: argininosuccinate lyase

essential: no

ec: 4.3.2.1

synonyms

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.4|Biosynthesis/ acquisition of arginine]

[SW|Categories] containing this gene/protein

• [SW|biosynthesis/ acquisition of amino acids]

This gene is a member of the following [SW|regulons]

• [SW|AhrC regulon]

The protein

Catalyzed reaction/ biological activity

• 2-(N(omega)-L-arginino)succinate = fumarate + L-arginine (according to Swiss-Prot)

Protein family

• Argininosuccinate lyase subfamily (according to Swiss-Prot)

Structure

• [PDB|1TJ7] (from ''Escherichia coli'', 47% identity, 64% similarity) [Pubmed|15502303]

[SW|Localization]

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operon

• ''[protein|search|argG]-[protein|search|argH]'' [Pubmed|22383849]

Regulation

• repressed by casamino acids [Pubmed|12107147]
• repressed by arginine ([protein|search|AhrC])

Regulatory mechanism

• [protein|search|AhrC]: transcription repression

References

• 12107147,21821766,22383849