modulation of CheA activity in response to attractants
function
control of CheA activity
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.2|Control of two-component response regulators] → [category|SW 3.4.2.2.3|Control of response regulators/ other][category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.1|Motility and chemotaxis] → [category|SW 4.1.1.1|Signal transduction in motility and chemotaxis] → [category|SW 4.1.1.1.2|Coupling proteins][category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.2|Biofilm formation] → [category|SW 4.1.2.6|Other proteins required for efficient pellicle biofilm formation][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.2|Phosphorylation on an Asp residue][SW|Categories] containing this gene/protein
[SW|transcription factors and their control], [SW|phosphoproteins], [SW|motility and chemotaxis]This gene is a member of the following [SW|regulons]
[SW|SigD regulon]Gene
Coordinates on the chromosome (coding sequence)
1,473,605 -> 1,474,516
Phenotypes of a mutant
''[protein|search|cheV] [protein|search|cheW]'' double mutants exhibit complete loss of chemotaxis [Pubmed|21098025]not essential for pellicle biofilm formation, but mutant is outcompeted by the wild-type strain when competed during pellicle formation [Pubmed|26122431]The protein
Paralogous protein(s)
[protein|search|CheW] (N-terminal domain of CheV)[SW|Domains]
N-terminal [protein|search|CheW]-like domain, C-terminal two-component receiver domain [Pubmed|11553614]Modification
the C-terminal two-component receiver domain is phosphorylated on a Asp residue by [protein|search|CheA] [Pubmed|11553614][SW|Localization]
forms lateral clusters (phosphorylated form), but in the presence of high asparagine concentration (non-phosphorylated form) there is a reversible re-localization to the poles of the cell [Pubmed|21098025][SW|Interactions]
[protein|search|CheA]-[protein|search|CheY] [Pubmed|11553614]Expression and Regulation
Operon
''[protein|search|cheV]'' [Pubmed|8169223][SW|Sigma factor]
[protein|search|SigD] [Pubmed|8169223]Additional information
in minimal medium, CheV is present with 7,500 /- 2,000 molecules per cell [PubMed|21515776] Biological materials
Mutant
DS70 (''cheV''::''mls'' in NCIB3610) [Pubmed|12864845]References
Reviews
Original publications
12864845,26122431,8169224,8169223,11553614,14731274,21098025,21515776 
