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noc [Tue Dec 13 2016 11:16:38 GMT+0100 (CET)]
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noc [Tue Dec 13 2016 11:16:38 GMT+0100 (CET)]

DNA-binding protein, spatial regulator of cell division to protect the nucleoid, and timing device with an important role in the coordination of chromosome segregation and cell division, Z ring placement
locus
BSU40990
pI
5.00
mw
32.00 kDa
function
control of cell division
product
effector of nucleoid occlusion
essential
no
synonyms
yyaA
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.8|Cell division] → [category|SW 1.1.8.2|Other genes]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • [SW|Categories] containing this gene/protein

  • [SW|cell division], [SW|membrane proteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|ComK regulon], [SW|DnaA regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    4,207,897 -> 4,208,748

    Phenotypes of a mutant

  • a ''[protein|search|yvcL] [protein|search|noc]'' double mutant grows poorly, and the cells are filamentous [Pubmed|24097947]

    • The protein

    Catalyzed reaction/ biological activity

  • binds specific sites on the chromosome [Pubmed|19494834]

    • Protein family

  • ParB family (according to Swiss-Prot)

    • Paralogous protein(s)

  • [SW|Spo0J]

    • [SW|Localization]

  • associated to the cell membrane [Pubmed|25568309]

    • Expression and Regulation

    Operon

  • ''[protein|search|thdF]-[protein|search|gidA]-[protein|search|rsmG]-[protein|search|noc]'' [Pubmed|11807071]

    • Regulation

  • constitutively expressed [Pubmed|23701187]

    • Regulatory mechanism

  • [protein|search|ComK]: transcription activation [Pubmed|11948146]
  • [protein|search|DnaA]: transcription repression [Pubmed|26020636]

    • Biological materials

    GFP fusion

  • available in the [SW|Jeff Errington] lab

    • Labs working on this gene/protein

  • Jeff Errington, Newcastle, UK [http://www.ncl.ac.uk/camb/staff/profile/jeff.errington Homepage]

    • References

    Reviews

  • 19680248,19884039,25460802,26706151

    • Original Publications

  • 16549676,11807071,19494834,15210112,11948146,22457634,23701187,24097947,25568309,26020636