phosphoribosylaminoimidazole carboxamide formyltransferase
function
purine biosynthesis
product
phosphoribosylaminoimidazole carboxamide formyltransferase
and inosine-monophosphate cyclohydrolase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.1|Biosynthesis/ acquisition of purine nucleotides][SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of nucleotides], [SW|most abundant proteins]This gene is a member of the following [SW|regulons]
[SW|G-box], [SW|PurR regulon]Gene
Coordinates on the chromosome (coding sequence)
708,594 -> 710,132
The protein
Catalyzed reaction/ biological activity
10-formyltetrahydrofolate 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (according to Swiss-Prot)Protein family
purH family (according to Swiss-Prot)Structure
[PDB|1ZCZ] (from ''Thermotoga maritima'', 36% identity, 54% similarity) [Pubmed|18260100]Expression and Regulation
Operon
''[protein|search|purE]-[protein|search|purK]-[protein|search|purB]-[protein|search|purC]-[protein|search|purS]-[protein|search|purQ]-[protein|search|purL]-[protein|search|purF]-[protein|search|purM]-[protein|search|purN]-[protein|search|purH]-[protein|search|purD]'' [Pubmed|3036807][SW|Sigma factor]
[protein|search|SigA] [Pubmed|3036807]Regulation
repressed in the presence of purine of purine nucleotides ([protein|search|PurR]) [Pubmed|7638212]repressed in the presence of adenine or adenosine([protein|search|PurR]) [Pubmed|2536750]repressed in the presence of guanine([protein|search|G-box]) [Pubmed|3036807]Regulatory mechanism
[protein|search|PurR]: transcription repression [Pubmed|7638212][protein|search|PurR]: transcription repression (molecular inducer: PRPP) [Pubmed|2536750][protein|search|G-box]: transcription termination/ antitermination ([SW|riboswitch]) [http://www.ncbi.nlm.nih.gov/sites/entrez/3036807 PubMed1] [http://www.ncbi.nlm.nih.gov/sites/entrez/12787499 PubMed2]Additional information
belongs to the 100 [[most abundant proteins]] [PubMed|15378759]References
3036807,12923093,15378759,7638212 
