thrD [Tue Dec 13 2016 11:16:30 GMT+0100 (CET)]

aspartokinase III

locus: BSU03790

pI: 4.00

mw: 49.00 kDa

function: unknown

product: aspartokinase III

essential: no

ec: 2.7.2.4

synonyms: yclM

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.6|Biosynthesis/ acquisition of lysine/ threonine]

[SW|Categories] containing this gene/protein

• [SW|biosynthesis/ acquisition of amino acids]

This gene is a member of the following [SW|regulons]

• [SW|CodY regulon], [SW|ThrR regulon]

Gene

Coordinates on the chromosome (coding sequence): 430,623 -> 431,987

The protein

Catalyzed reaction/ biological activity

• ATP L-aspartate = ADP 4-phospho-L-aspartate (according to Swiss-Prot)

Protein family

• aspartokinase family (according to Swiss-Prot)

Effectors of protein activity

• inhibited by the simultaneous presence of threonine and lysine [Pubmed|11471740]

Expression and Regulation

Operon

• ''thrD'' [Pubmed|22383849]

Regulation

• expressed in the presence of lysine or cysteine ([SW|ThrR]) [Pubmed|27260660]

Regulatory mechanism

• [protein|search|CodY]: transcription repression [Pubmed|23569278]
• [protein|search|ThrR]: transcription repression [Pubmed|27260660]

Biological materials

lacZ fusion

• pBP318 (in [protein|search|pAC5]), available in [SW|Fabian Commichau]'s lab [Pubmed|27260660]

References

Reviews

• 19946135,22079167

Original publications

• 11471740,23569278,2152900,2153658,22383849,27260660