proH [Tue Dec 13 2016 11:16:33 GMT+0100 (CET)]

pyrroline-5-carboxylate reductase

locus: BSU18480

pI: 7.00

mw: 31.00 kDa

function: osmoadaptive de novo production of proline

product: pyrroline-5-carboxylate reductase

essential: no

ec: 1.5.1.2

synonyms: yoxE

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.2|Biosynthesis/ acquisition of proline]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.6|Coping with hyper-osmotic stress]

[SW|Categories] containing this gene/protein

• [SW|biosynthesis/ acquisition of amino acids], [SW|coping with hyper-osmotic stress]

Gene

Coordinates on the chromosome (coding sequence): 2,016,845 -> 2,017,738

The protein

Catalyzed reaction/ biological activity

• L-proline NAD(P) = 1-pyrroline-5-carboxylate NAD(P)H (according to Swiss-Prot)

Protein family

• glutamate 5-kinase family (according to Swiss-Prot)

Paralogous protein(s)

• [protein|search|ProI]

Structure

• [PDB|5BSE] (from ''Medicago trunculata'', 36% identity)

[SW|Localization]

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operon

• ''[protein|search|proH]-[protein|search|proJ]'' [Pubmed|21296969]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|21784929]

Regulation

• expressed under conditions of osmotic stress [Pubmed|21784929]
• induced by cold stress [Pubmed|21296969]
• expression during spore [SW|germination] is increased under conditions of osmotic stress [Pubmed|27766092]

References

Reviews

• 25367752

Original publications

• 11418582,21296969,25344233,21784929,27766092