SubtiBank SubtiBank
secY [Mon Sep 26 2016 18:24:29 GMT+0200 (CEST)]
You are currently viewing an outdated version of SubtiWiki. Please use the newest version!

secY [Mon Sep 26 2016 18:24:29 GMT+0200 (CEST)]

preprotein translocase subunit, universally conserved protein
locus
BSU01360
pI
10.00
mw
47.00 kDa
function
protein secretion
product
preprotein translocase subunit
essential
yes
synonyms

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.5|Protein secretion]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • [category|SW 6|Groups of genes] → [category|SW 6.5|Universally conserved proteins]
  • [SW|Categories] containing this gene/protein

  • [SW|protein secretion], [SW|essential genes], [SW|membrane proteins], [SW|universally conserved proteins]
  • This gene is a member of the following [SW|regulons]

  • [SW|stringent response]
  • Gene

    Coordinates on the chromosome (coding sequence)
    144,527 -> 145,822

    Phenotypes of a mutant

  • essential [Pubmed|12682299]
  • terminal phenotype of CRISPRi knockdown mutant is moderate bending and cessation of growth [Pubmed|27238023]
  • The protein

    Protein family

  • secY/SEC61-alpha family (according to Swiss-Prot)
  • Structure

  • [PDB|3DL8] (structure of the ([protein|search|SecY]-[protein|search|SecE]-[protein|search|SecG])-[protein|search|SecA] complex [Pubmed|18923516]
  • [SW|Localization]

  • membrane [Pubmed|18763711]
  • [SW|Interactions]

  • ([protein|search|SecY]-[protein|search|SecE]-[protein|search|SecG])2-[protein|search|SecA]2 [Pubmed|18923516]
  • [protein|search|FloT]-[protein|search|SecY] [Pubmed|23651456]
  • [protein|search|SecY]-[protein|search|FtsY] [Pubmed|21255212]
  • Additional information

  • [SW|universally conserved protein]
  • Expression and Regulation

    Operon

  • rplO-secY-adk-map
  • Regulation

  • [protein|search|RelA] dependent downregulation (Class I) during stringent response [Pubmed|11948165]
  • Biological materials

    Mutant

  • Pspac-secY [Pubmed|8071801]
  • BEC01360, a CRISPRi knockdown mutant, is available from the [http://bgsc.org Bacillus Genetic Stock Center]
  • References

    Reviews

  • 25212246
  • Original publications

  • 27238023,2110998,12242434,8635744,23651456,18763711,8071801,8635744,18923516,23852076,26747607,27336478,21255212