SubtiBank SubtiBank
cysH [Fri Nov 13 2015 17:04:35 GMT+0100 (CET)]
You are currently viewing an outdated version of SubtiWiki. Please use the newest version!

cysH [Fri Nov 13 2015 17:04:35 GMT+0100 (CET)]

phosphoadenosine phosphosulfate sulfotransferase
locus
BSU15570
pI
5.00
mw
26.00 kDa
function
sulfate reduction
product
phosphoadenosine phosphosulfate sulfotransferase
essential
no
ec
1.8.4.8
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.4|Sulfur metabolism]
  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.4|Sulfur metabolism] → [category|SW 2.6.4.2|sulfur metabolism/ general]

    • [SW|Categories] containing this gene/protein

  • [SW|sulfur metabolism]

    • This gene is a member of the following [SW|regulons]

  • [SW|CymR regulon], [SW|S-box]

    • Gene

    Coordinates on the chromosome (coding sequence)
    1,630,382 -> 1,631,083

    The protein

    Catalyzed reaction/ biological activity

  • Adenosine 3',5'-bisphosphate sulfite thioredoxin disulfide = 3'-phosphoadenylyl sulfate thioredoxin (according to Swiss-Prot)

    • Protein family

  • CysH subfamily (according to Swiss-Prot)

    • Paralogous protein(s)

  • [protein|search|YitB]

    • Structure

  • [http://pdb.org/pdb/explore/explore.do?structureId=2goy 2GOY] (from ''Pseudomonas aeruginosa'', 35% identity) [Pubmed|17010373]

    • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)

    • Expression and Regulation

    Operon

  • ''[protein|search|cysH]-[protein|search|cysP]-[protein|search|sat]-[protein|search|cysC]-[protein|search|ylnD]-[protein|search|ylnE]-[protein|search|ylnF]'' [Pubmed|11004190]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|11004190]

    • Regulation

  • repressed by casamino acids [Pubmed|12107147]
  • repressed in the presence of cysteine ([protein|search|CymR])
  • induced by methionine starvation ([protein|search|S-box]) [Pubmed|10094622]

    • Regulatory mechanism

  • [protein|search|S-box]: transcription termination/ antitermination, the [protein|search|S-box] [SW|riboswitch] binds S-adenosylmethionine resulting in termination [Pubmed|10094622]
  • [protein|search|CymR]: transcription repression

    • Labs working on this gene/protein

  • [[Isabelle Martin-Verstraete]], Institute Pasteur, Paris, France

    • References

  • 10094622,16267287,11004190,12107147,18039762,9006060,17010373