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cpgA [Tue Dec 13 2016 11:16:33 GMT+0100 (CET)]
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cpgA [Tue Dec 13 2016 11:16:33 GMT+0100 (CET)]

GTPase, activity stimulated by ribosomes, may be involved in ribosome maturation
locus
BSU15780
pI
4.74
mw
33.00 kDa
function
ribosome assembly, coordination of peptidoglycan deposition in the cell wall
product
GTPase
essential
no
synonyms
yloQ

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.5|Cell wall/ other]
  • [category|SW 2|Metabolism] → [category|SW 2.7|Detoxification reactions]
  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.9|Newly identified competence genes]
  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.6|Ribosome assembly]
  • [category|SW 6|Groups of genes] → [category|SW 6.3|GTP-binding proteins]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.6|Phosphorylation on a Thr residue]
  • [SW|Categories] containing this gene/protein

  • [SW|cell wall/ other], [SW|translation], [SW|GTP-binding proteins], [SW|phosphoproteins]
  • Gene

    Coordinates on the chromosome (coding sequence)
    1,653,103 -> 1,653,999

    Phenotypes of a mutant

  • forms curly cells [Pubmed|22544754]
  • The protein

    Protein family

  • engC GTPase domain (according to Swiss-Prot)
  • Modification

  • ''in vitro'' phosphorylated on Thr-166 by [protein|search|PrkC], dephosphorylated by [protein|search|PrpC] [Pubmed|22544754,19246764]
  • Structure

  • [PDB|1T9H]
  • [SW|Interactions]

  • binds the 30S subunit of the ribosome [Pubmed|22544754]
  • Expression and Regulation

    Operon

  • ''[protein|search|prpC]-[protein|search|prkC]-[protein|search|cpgA]'' [Pubmed|16025310]
  • ''[protein|search|cpgA]'' [Pubmed|16025310]
  • Labs working on this gene/protein

  • [SW|Tony Wilkinson], York University, U.K. [http://www.york.ac.uk/depts/chem/staff/ajw.html homepage]
  • References

    Reviews

  • 19575570
  • Original publications

  • 15223319,16485133,14747714,22544754,18344364,19246764,19246764,15828870,17005971,18344364,18984160