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cpgA [2017-8-11 16:0:3]
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cpgA [2017-8-11 16:0:3]

GTPase, activity stimulated by ribosomes, may be involved in ribosome maturation
locus
BSU15780
pI
4.74
mw
33.64 kDa
protein length
298 aa Sequence Blast
gene length
894 bp Sequence Blast
function
ribosome assembly, coordination of peptidoglycan deposition in the cell wall
product
GTPase
essential
no
synonyms
yloQ

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.5|Cell wall/ other]
  • [category|SW 2|Metabolism] → [category|SW 2.7|Detoxification reactions]
  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.9|Newly identified competence genes]
  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.6|Ribosome assembly]
  • [category|SW 6|Groups of genes] → [category|SW 6.3|GTP-binding proteins]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.6|Phosphorylation on a Thr residue]
  • Gene

    Coordinates
    1,653,103 → 1,653,999

    Phenotypes of a mutant

  • forms curly cells [Pubmed|22544754]
  • The protein

    Protein family

  • engC GTPase domain (according to Swiss-Prot)
  • Modification

  • ''in vitro'' phosphorylated on Thr-166 by [protein|23FF4A00C36EC1B7297F51A9EF3579B41F0B7EBA|PrkC], dephosphorylated by [protein|84447F9A6644EA8A7593BB99B2B69D4377E670E2|PrpC] [Pubmed|22544754,19246764]
  • Structure

  • [PDB|1T9H]
  • Expression and Regulation

    Operons

    genes
    [gene|84447F9A6644EA8A7593BB99B2B69D4377E670E2|prpC]-[gene|23FF4A00C36EC1B7297F51A9EF3579B41F0B7EBA|prkC]-[gene|519D4694B2895EE6F0D38D918F52F27734506848|cpgA]-[gene|8103B8539338B77CF51B16B7FA76783ED2319F13|rpe]-[gene|0ACE023DCD6A6BB5A1827D1D997BDFAC3B168C51|yloS]
    description
    [Pubmed|22383849]
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    genes
    [gene|519D4694B2895EE6F0D38D918F52F27734506848|cpgA]
    description
    [Pubmed|16025310]
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    Biological materials

    Mutant

  • MGNA-B135 (yloQ::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1134 NBRP B. subtilis, Japan]
  • Labs working on this gene/protein

  • [SW|Tony Wilkinson], York University, U.K. [http://www.york.ac.uk/depts/chem/staff/ajw.html homepage]
  • References

    Reviews

  • 19575570
  • Original publications

  • 15223319,16485133,14747714,22544754,18344364,19246764,19246764,15828870,17005971,18344364,18984160