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feuA [Tue Oct 13 2015 12:40:43 GMT+0200 (CEST)]
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feuA [Tue Oct 13 2015 12:40:43 GMT+0200 (CEST)]

ABC transporter for the siderophores Fe-enterobactin and Fe-bacillibactin (binding protein), with YusV as ATPase
locus
BSU01630
pI
8.00
mw
34.00 kDa
function
acquisition of iron
product
ABC transporter for the siderophores Fe-enterobactin
and Fe-bacillibactin (binding protein)
essential
no
synonyms

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.1|Importers] → [category|SW 1.2.1.1.5|Uptake of iron/ siderophores]
  • [category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.3|Acquisition of iron] → [category|SW 1.3.3.1|ABC transporters for the uptake of iron/ siderophores]
  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.5|Iron metabolism] → [category|SW 2.6.5.4|ABC transporters for the uptake of iron/ siderophores]
  • [category|SW 6|Groups of genes] → [category|SW 6.12|Secreted proteins]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • [SW|Categories] containing this gene/protein

  • [SW|ABC transporters], [SW|acquisition of iron], [SW|iron metabolism], [SW|membrane proteins]
  • This gene is a member of the following [SW|regulons]

  • [SW|Btr regulon], [SW|CitB regulon], [SW|Fur regulon]
  • The protein

    Protein family

  • Fe/B12 periplasmic-binding domain (according to Swiss-Prot)
  • [SW|Domains]

  • Two independent non-symmetric globular domains, connected by a long alpha-helix (residues 143-164 of the mature protein).
  • Modification

  • FeuA is a lipoprotein with a N-acetyl-S-diacyl-glyceryl-cysteine structure [Pubmed|22303020]
  • Structure

  • [PDB|2PHZ], [PDB|2WI8], [PDB|2WHY] (complex with ferri-bacillibactin), [PDB|2XUZ] (complex with ferri-enterobactin), [PDB|2XV1] (complex with ferric mecam)
  • [SW|Localization]

  • associated to the membrane (lipoprotein) [Pubmed|22303020]
  • extracellular (signal peptide) [Pubmed|18957862]
  • [SW|Interactions]

  • [protein|search|YusV]-([protein|search|FeuB]-[protein|search|FeuC])-[protein|search|FeuA] [Pubmed|10092453]
  • Expression and Regulation

    Operon

  • ''[protein|search|feuA]-[protein|search|feuB]-[protein|search|feuC]-[protein|search|ybbA]'' [Pubmed|12354229]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|17725565]
  • Regulation

  • repressed in the presence of iron ([protein|search|Fur], [protein|search|CitB]) [Pubmed|12354229]
  • induced in the presence of iron chelators bacillibactin or enterobactin ([protein|search|Btr]) [Pubmed|17725565]
  • Regulatory mechanism

  • [protein|search|Fur]: transcription repression [Pubmed|12354229]
  • [protein|search|CitB]: binding to the iron responsive element in the absence of iron
  • [protein|search|Btr]: transcription activation in the presence of the co-activators bacillibactin or enterobactin [Pubmed|17725565]
  • References

  • 20086155,19746494,19673474,14563870,16672620,10092453,16889643,17725565,12354229,18957862,18763711,22303020