ykkD [Wed Dec 21 2016 18:09:47 GMT+0100 (CET)]

similar to molecular chaperone

locus: BSU13100

pI: 8.00

mw: 11.00 kDa

function: unknown

product: unknown

essential: no

synonyms

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.11|Other exporters]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

[SW|Categories] containing this gene/protein

• [SW|chaperones/ protein folding], [SW|membrane proteins]

Gene

Coordinates on the chromosome (coding sequence): 1,376,855 -> 1,377,172

The protein

Protein family

• paired small multidrug resistance protein family ([SW|PSMR family]) [Pubmed|17942072]

[SW|Localization]

• cell membrane (according to Swiss-Prot)

[SW|Interactions]

• [SW|YkkC]-[SW|YkkD] (likely) [Pubmed|17942072]

Expression and Regulation

Operon

• ''[protein|search|ykkC]-[protein|search|ykkD]'' [Pubmed|10735877]

Regulation

• induced in the presence of guanidine ([SW|ykkC riboswitch]) [Pubmed|27989440]

Regulatory mechanism

• [SW|ykkC riboswitch]: binding of the ligand guanidine causes transcriptional antitermination [Pubmed|27989440]
• term-seq has identified a potential novel regulatory RNA element including an intrinsic transcription terminator upstream of ''ykkC'' [Pubmed|27120414]

Biological materials

Mutant

• MGNA-A748 (ykkD::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/748 NBRP B. subtilis, Japan]

References

Reviews

• 17942072

Original publications

• 10735877,21317561,27989440,27120414