cysteine desulfurase, sulfur transfer to TrmU, involved in 2-thiouridine (s2U) modification of the wobble position in glutamate, glutamine and lysine tRNA molecules
function
tRNA modification
product
cysteine desulfurase
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.8|tRNA modification and maturation][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.1|Phosphorylation on an Arg residue][SW|Categories] containing this gene/protein
[SW|essential genes], [SW|translation], [SW|phosphoproteins]This gene is a member of the following [SW|regulons]
[SW|stringent response]Gene
Coordinates on the chromosome (coding sequence)
2,810,559 -> 2,811,698
Phenotypes of a mutant
essential [Pubmed|12682299]The protein
Catalyzed reaction/ biological activity
2-thiouridine (s2U) modification of the wobble position in glutamate, glutamine and lysine tRNA molecules (together with [protein|search|TrmU]) [Pubmed|25825430]Paralogous protein(s)
[protein|search|NifS], [protein|search|NifZ], [protein|search|SufS], [protein|search|YcbU]Modification
phosphorylated on Arg-385 [Pubmed|22517742]Structure
[PDB|1EG5] (from Thermotoga maritima, 37% identity, 54% similarity) [Pubmed|10715213][SW|Interactions]
[protein|search|YrvO]-[protein|search|TrmU] [Pubmed|25825430]Expression and Regulation
Operon
''[protein|search|cymR]-[protein|search|yrvO]-[protein|search|trmU]'' [Pubmed|16885442][SW|Sigma factor]
[protein|search|SigA] [Pubmed|16885442]Regulation
[protein|search|RelA] dependent downregulation (Class I) during stringent response [Pubmed|11948165]References
16885442,11948165,10715213,22517742,12682299,17064282,25825430 
