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trxA [Tue Dec 15 2015 03:30:15 GMT+0100 (CET)]
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trxA [Tue Dec 15 2015 03:30:15 GMT+0100 (CET)]

thioredoxin, antioxidative action by facilitating the reduction of other proteins by cysteine thiol-disulfide exchange, important for the prevention of protein aggregation during severe heat stress
locus
BSU28500
pI
4.00
mw
11.00 kDa
function
protection of proteins against oxidative damage
product
thioredoxin
essential
yes
synonyms
trx
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.1|Electron transport and ATP synthesis] → [category|SW 2.1.3|Electron transport/ other]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.1|General stress proteins (controlled by SigB)]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

    • [SW|Categories] containing this gene/protein

  • [SW|electron transport/ other], [SW|general stress proteins (controlled by SigB)], [SW|resistance against oxidative and electrophile stress], [SW|essential genes]

    • This gene is a member of the following [SW|regulons]

  • [SW|CtsR regulon], [SW|SigB regulon], [SW|Spx regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    2,913,024 -> 2,913,338

    Phenotypes of a mutant

  • essential [Pubmed|12682299]

    • The protein

    Protein family

  • thioredoxin family (according to Swiss-Prot)

    • Structure

  • [PDB|2GZZ] (oxidized form), [PDB|2GZY] (reduced form), [PDB|2IPA] (TrxA-ArsC-complex) [Pubmed|17303556]

    • [SW|Localization]

  • cytoplasm [Pubmed|17501922]

    • [SW|Interactions]

  • [protein|search|ArsC]-[protein|search|TrxA] [Pubmed|17303556]

    • Expression and Regulation

    Operon

  • ''trxA'' [Pubmed|9537387]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|9537387], [protein|search|SigB] [Pubmed|9537387,11544224]

    • Regulation

  • induced by stress ([protein|search|SigB]) [Pubmed|11544224]
  • regulation by [protein|search|Spx] in response to diamide stress
  • induced by heat stress ([protein|search|CtsR]) [Pubmed|9852015]

    • Regulatory mechanism

  • [protein|search|CtsR]: transcription repression [Pubmed|9852015]

    • Additional information

  • A [protein|search|ncRNA] is predicted between '[protein|search|trxA]' and '[protein|search|abf2]' [PubMed|20525796]

    • References

    Reviews

  • 23899494

    • Original publications

  • 9537387,15937154,18601268,18456801,9852015,11544224,18687074,20084284,17303556,12642660,20525796,17501922,24401092,24417481