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gabT [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]
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gabT [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]

gamma-aminobutyrate transaminase, general stress protein
locus
BSU03900
pI
5.30
mw
47.00 kDa
function
utilization of gamma-amino butyric acid
product
gamma-aminobutyrate transaminase
essential
no
ec
2.6.1.19
synonyms
ycnG

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.2|Utilization of amino acids] → [category|SW 2.3.2.10|Utilization of gamma-amino butyric acid]
  • [SW|Categories] containing this gene/protein

  • [SW|utilization of amino acids]
  • This gene is a member of the following [SW|regulons]

  • [SW|GabR regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    441,571 -> 442,881

    Phenotypes of a mutant

  • growth defect in the presence of gamma-aminobutyrate [Pubmed|24127574]
  • no growth with gamma-aminobutyrate as single carbon source [Pubmed|24529384]
  • The protein

    Catalyzed reaction/ biological activity

  • 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate (according to Swiss-Prot)
  • the protein was reported to be involved in norspermidine production and biofilm disassembly [Pubmed|22541437]; however, this is not the case [Pubmed|24529384]and the original paper has been [http://www.cell.com/cell/fulltext/S0092-8674%2815%2900495-X retracted]
  • Protein family

  • class-III pyridoxal-phosphate-dependent aminotransferase family (according to Swiss-Prot)
  • Expression and Regulation

    Operon

  • ''[protein|search|gabT]-[protein|search|gabD]'' [Pubmed|12123465]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|12123465]
  • Regulation

  • expressed in the presence of gamma-butyric acid and pyridoxal 5'-phosphate ([protein|search|GabR]) [Pubmed|12123465]
  • Regulatory mechanism

  • [protein|search|GabR]: transcription activation [Pubmed|12123465]
  • Labs working on this gene/protein

  • [SW|Linc Sonenshein], Tufts University, Boston, MA, USA [http://www.tufts.edu/sackler/microbiology/faculty/sonenshein/index.html Homepage]
  • References

  • 15223311,12123465,22541437,24529384,4590473