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yhdN [2017-05-17 11:12:48]
general stress protein, broad specificity aldo-keto reductase that converts MG to acetol
function
detoxification of methylglyoxal
product
aldo/keto reductase, specific for NADP
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.2|Biosynthesis of lipids] → [category|SW 2.4.2.1|Biosynthesis of fatty acids][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.1|General stress proteins (controlled by SigB)][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress]Gene
Coordinates
1,030,265 → 1,031,260
Phenotypes of a mutant
increased sensitivity to methylglyoxal [Pubmed|24330391]The protein
Catalyzed reaction/ biological activity
methylglyoxal -→ acetol [Pubmed|24330391]Protein family
aldo/keto reductase 2 family (according to Swiss-Prot)Paralogous protein(s)
[protein|F1AFFACD36C75702B0BB8F0B4241A9688FB6253C|IolS], [protein|B73D729097C00BE6F3C7FF1708738783EE93C6FB|YccK][SW|Cofactors]
NADPH [Pubmed|24330391]Structure
[PDB|1PZ1] [Pubmed|15019785]Biological materials
Mutant
MGNA-A695 (yhdN::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/695 NBRP B. subtilis, Japan]References
10220166,15019785,24330391,12737802,15805528