SubtiBank SubtiBank
gamP [Tue Dec 13 2016 11:16:30 GMT+0100 (CET)]
The second international online conference #Subtillery2021 will be held 14th - 18th June - save the date, for more information see the conference website!

The 21st International Conference on Bacilli has been postponed to 2022 and will take place in Prague.

gamP [Tue Dec 13 2016 11:16:30 GMT+0100 (CET)]

glucosamine-specific phosphotransferase system, EIICBA of the PTS
locus
BSU02350
pI
5.47
mw
67.00 kDa
function
glucosamine uptake and phosphorylation
product
glucosamine-specific phosphotransferase system, EIICBA
essential
no
ec
2.7.1.69
synonyms
ybfS, yzfA

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.3|Cell wall degradation/ turnover] → [category|SW 1.1.3.3|Utilization of cell wall components]
  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.2|Phosphotransferase system] → [category|SW 1.2.2.2|Sugar specific PTS proteins]
  • [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.17|Utilization of amino sugars]
  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.3|Utilization of nitrogen sources other than amino acids] → [category|SW 2.3.3.3|Utilization of amino sugars]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.3|Phosphorylation on a Cys residue]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.4|Phosphorylation on a His residue]
  • [SW|Categories] containing this gene/protein

  • [SW|cell wall degradation/ turnover], [SW|phosphotransferase systems], [SW|utilization of specific carbon sources], [SW|membrane proteins], [SW|phosphoproteins]
  • This gene is a member of the following [SW|regulons]

  • [SW|GamR regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    254,907 -> 256,802

    Phenotypes of a mutant

  • delayed growth with glucosamine as the single carbon source [Pubmed|10627040]
  • The protein

    Catalyzed reaction/ biological activity

  • protein EIIA N(pi)-phospho-L-histidine + protein EIIB = protein EIIA + protein EIIB N(pi)-phospho-L-histidine/cysteine (according to Swiss-Prot)
  • Protein family

  • [SW|PTS] permease, glucose permease (Glc) family [Pubmed|10627040]
  • Paralogous protein(s)

  • [protein|search|NagP]
  • [SW|Localization]

  • membrane [Pubmed|18763711]
  • [SW|Interactions]

  • [protein|search|GamP]-[PtsH|search|HPr]
  • Expression and Regulation

    Operon

  • ''[protein|search|gamA]-[protein|search|gamP]'' [Pubmed|23667565]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|23667565]
  • Regulation

  • induced by glucosamine ([protein|search|GamR]) [Pubmed|24673833,23667565]
  • Regulatory mechanism

  • [protein|search|GamR]: transcription repression [Pubmed|24673833,23667565]
  • Biological materials

    Mutant

  • QB6098 (aphA3), available in [SW|Stülke] lab
  • References

  • 10627040,18763711,24673833,23667565