glucosamine-specific phosphotransferase system, EIICBA of the PTS
function
glucosamine uptake and phosphorylation
product
glucosamine-specific phosphotransferase system, EIICBA
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.3|Cell wall degradation/ turnover] → [category|SW 1.1.3.3|Utilization of cell wall components][category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.2|Phosphotransferase system] → [category|SW 1.2.2.2|Sugar specific PTS proteins][category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.17|Utilization of amino sugars][category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.3|Utilization of nitrogen sources other than amino acids] → [category|SW 2.3.3.3|Utilization of amino sugars][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.3|Phosphorylation on a Cys residue][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.4|Phosphorylation on a His residue][SW|Categories] containing this gene/protein
[SW|cell wall degradation/ turnover], [SW|phosphotransferase systems], [SW|utilization of specific carbon sources], [SW|membrane proteins], [SW|phosphoproteins]This gene is a member of the following [SW|regulons]
[SW|GamR regulon]Gene
Coordinates on the chromosome (coding sequence)
254,907 -> 256,802
Phenotypes of a mutant
delayed growth with glucosamine as the single carbon source [Pubmed|10627040]The protein
Catalyzed reaction/ biological activity
protein EIIA N(pi)-phospho-L-histidine + protein EIIB = protein EIIA + protein EIIB N(pi)-phospho-L-histidine/cysteine (according to Swiss-Prot)Protein family
[SW|PTS] permease, glucose permease (Glc) family [Pubmed|10627040]Paralogous protein(s)
[protein|search|NagP][SW|Localization]
membrane [Pubmed|18763711][SW|Interactions]
[protein|search|GamP]-[PtsH|search|HPr]Expression and Regulation
Operon
''[protein|search|gamA]-[protein|search|gamP]'' [Pubmed|23667565][SW|Sigma factor]
[protein|search|SigA] [Pubmed|23667565]Regulation
induced by glucosamine ([protein|search|GamR]) [Pubmed|24673833,23667565]Regulatory mechanism
[protein|search|GamR]: transcription repression [Pubmed|24673833,23667565]Biological materials
Mutant
QB6098 (aphA3), available in [SW|Stülke] labReferences
10627040,18763711,24673833,23667565 
