SubtiBank SubtiBank
thrC [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]
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The 21st International Conference on Bacilli has been postponed to 2022 and will take place in Prague.

thrC [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]

threonine synthase
locus
BSU32250
pI
5.00
mw
37.00 kDa
function
biosynthesis of threonine
product
threonine synthase
essential
no
ec
4.2.3.1
synonyms
thrB

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.6|Biosynthesis/ acquisition of lysine/ threonine]
  • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis/ acquisition of amino acids], [SW|most abundant proteins]
  • This gene is a member of the following [SW|regulons]

  • [SW|CodY regulon], [SW|ThrR regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    3,313,770 -> 3,314,828

    The protein

    Catalyzed reaction/ biological activity

  • O-phospho-L-homoserine H2O = L-threonine phosphate (according to Swiss-Prot)
  • Protein family

  • serine/threonine dehydratase family (according to Swiss-Prot)
  • Structure

  • [PDB|1UIN] (from ''Thermus thermophilus'', 51% identity, 69% similarity) [Pubmed|12952961]
  • Expression and Regulation

    Operon

  • ''[protein|search|hom]-[protein|search|thrC]-[protein|search|thrB]'' [Pubmed|12107147]
  • Regulation

  • repressed by casamino acids [Pubmed|12107147]
  • repressed during growth in the presence of branched chain amino acids ([protein|search|CodY]) [Pubmed|24163341]
  • Regulatory mechanism

  • [protein|search|CodY]: transcription repression [Pubmed|24163341]
  • [protein|search|ThrR]: transcription repression [Pubmed|27260660]
  • Additional information

  • belongs to the 100 [SW|most abundant proteins] [PubMed|15378759]
  • Biological materials

    Mutant

  • 1A773 ( ''thrC''::''cat''), [Pubmed|8973347], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A773&Search=1A773 BGSC] and in [SW|Jörg Stülke]'s lab
  • References

  • 12107147,3098560,24163341,15378759,27260660