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uppS
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uppS

undecaprenyl pyrophosphate synthetase, provides the precursor for the carrier lipid, undecaprenyl phosphate (C55-P), which is required for cell wall synthesis
locus
BSU_16530
pI
5.41
mw
29.63 kDa
protein length
260 aa Sequence Blast
gene length
783 bp Sequence Blast
function
cell wall biosynthesis
product
undecaprenyl pyrophosphate synthetase
essential
yes
ec
2.5.1.31
synonyms
yluA
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.8|Biosynthesis of the carrier lipid undecaprenylphosphate]
  • [category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.2|Biosynthesis of lipids] → [category|SW 2.4.2.3|Biosynthesis of isoprenoids]
  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.1|Biosynthesis of cell wall components] → [category|SW 2.6.1.5|Biosynthesis of the carrier lipid undecaprenylphosphate]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

    • Gene

    Coordinates
    1,721,214 1,721,996

    Phenotypes of a mutant

  • essential [Pubmed|22904278]
  • ''uppS'' is dispensable in wall-less L-forms [Pubmed|24704074]
  • the ''[SW|uppS86]'' (C257T) mutation provides resistance to rare earth metals such as scandium and to bacitracin [Pubmed|22904278]

    • The protein

    Catalyzed reaction/ biological activity

  • catalyzes eight consecutive condensation reactions of isopentenyl pyrophosphate (IPP) with farnesyl pyrophosphate (FPP) to form undecaprenyl pyrophosphate

    • Protein family

  • UPP synthetase family (single member, according to UniProt)

    • Structure

  • [PDB|1X09] (the protein from ''E. coli'', 49% identity, 77% similarity) [Pubmed|15788389]

    • Expression and Regulation

    Operons

    genes
    [gene|4A637EB9B400D30E5C6246D1E0EB5E6A30F38A16|uppS]-[gene|7E7F6BBA03C443A5AFA05A6D9352FEF1212A5AF6|cdsA]-[gene|58CDF08A8F05C0BC25EB6E400316F85FD0F307E5|ispC]-[gene|CB50289535EA537F63BADD459BD11AA7759A6658|rasP]-[gene|848570563D3C92A8E1E6AB4DA530388D8AE94E75|proS]-[gene|FB97DF0C147FB29944F60214CB9BC1803861DAA0|polC]
    description
    [Pubmed|22383849]
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    Biological materials

    Mutant

  • MGNA-B080 (yluA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1079 NBRP B. subtilis, Japan]

    • References

  • 22904278,23796923,15788389,23840410,24704074,27578312