SubtiBank SubtiBank
yhdL
An ordered knock out library of all non-essential genes in B. subtilis is now available at Addgene. Information on ordering a copy can be found here. See Koo et al. 2017 for details about library construction.

yhdL

anti-[protein|081DF3EE9FA56209D648C7677188C61CE3AA8E41|SigM] protein
locus
BSU09510
pI
6.18
mw
40.42 kDa
protein length
358 aa Sequence Blast
gene length
1074 bp Sequence Blast
function
control of [protein|081DF3EE9FA56209D648C7677188C61CE3AA8E41|SigM] activity
product
anti-[protein|081DF3EE9FA56209D648C7677188C61CE3AA8E41|SigM] protein
essential
yes
synonyms

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.1|Sigma factors and their control] → [category|SW 3.4.1.2|Control of sigma factors]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.2|Cell envelope stress proteins (controlled by SigM, V, W, X, Y)]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • Gene

    Coordinates
    1,028,511 → 1,029,587

    Phenotypes of a mutant

  • essential [Pubmed|12682299]
  • The protein

    [SW|Localization]

  • cell membrane [Pubmed|14993308]
  • Expression and Regulation

    Operons

    genes
    [gene|081DF3EE9FA56209D648C7677188C61CE3AA8E41|sigM]-[gene|48975EC8FB5B03F136AA112DE2ED9CFD0E9C4141|yhdL]-[gene|43AD66E4AEE951130F134FD720E17DB4D2FF112E|yhdK]
    description
    [Pubmed|9573210]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|9573210], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]
  • [protein|081DF3EE9FA56209D648C7677188C61CE3AA8E41|SigM]: sigma factor, [Pubmed|9573210,18179421], in [regulon|081DF3EE9FA56209D648C7677188C61CE3AA8E41|SigM regulon]
  • regulation

  • induced by glucose [Pubmed|27965645]
  • additional information

  • expression of [protein|search|CsbB] in the absence of [protein|search|YfhO] causes constitutive activation of [protein|search|SigM] [PubMed|23632331]
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    Biological materials

    Mutant

  • MGNA-B482 (yhdL::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1481 NBRP B. subtilis, Japan]
  • BP97 (''Δ[gene|081DF3EE9FA56209D648C7677188C61CE3AA8E41|sigM]-[gene|48975EC8FB5B03F136AA112DE2ED9CFD0E9C4141|yhdL]-[gene|43AD66E4AEE951130F134FD720E17DB4D2FF112E|yhdK]::aphA3''), available in [SW|Fabian Commichau]'s lab
  • References

    Reviews

  • 27344142
  • Original publications

  • 18179421,14993308,10216858,26399770