3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA)
function
fatty acid degradation
product
3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA)
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.1|Utilization of lipids] → [category|SW 2.4.1.3|Utilization of fatty acids][SW|Categories] containing this gene/protein
[SW|utilization of lipids], [SW|sporulation proteins]This gene is a member of the following [SW|regulons]
[SW|CcpA regulon], [SW|FadR regulon], [SW|SdpR regulon]Gene
Coordinates on the chromosome (coding sequence)
3,370,025 -> 3,372,472
The protein
Catalyzed reaction/ biological activity
(S)-3-hydroxyacyl-CoA NAD = 3-oxoacyl-CoA NADH (according to Swiss-Prot)Protein family
3-hydroxyacyl-CoA dehydrogenase family (according to Swiss-Prot)[SW|Cofactors]
FMN or FAD [Pubmed|21635694]Expression and Regulation
Operon
''[protein|search|fadM]-[protein|search|fadN]-[protein|search|fadA]-[protein|search|fadE]'' [Pubmed|17189250]''[protein|search|fadN]-[protein|search|fadA]-[protein|search|fadE]'' [Pubmed|17189250][SW|Sigma factor]
''[protein|search|fadN]'': [protein|search|SigA] [Pubmed|17189250]Regulation
''[protein|search|fadN]'': induced by long-chain fatty acids ([protein|search|FadR]) [Pubmed|17189250]''[protein|search|fadN]'': subject to carbon catabolite repression ([protein|search|CcpA]-[PtsH|search|HPr(Ser-P)] [Pubmed|12850135,21398533]strongly induced in response to glucose starvation in M9 medium [Pubmed|23033921]Regulatory mechanism
[protein|search|FadR]: transcription repression [Pubmed|17189250][protein|search|SdpR]: transcription activation [Pubmed|12817086][protein|search|CcpA]-[PtsH|search|HPr(Ser-P)]: transcription repression [Pubmed|21398533]References
12817086,12850135,17189250,17919287,23033921,21398533 
