yxdM

[SW|ABC transporter] (permease)

locus: BSU_39630

pI: 9.27

mw: 70.35 kDa

protein length: 622 aa

gene length: 1869 bp

function: export of toxic peptides

product: [SW|ABC transporter] (permease)

essential: no

synonyms

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.2|Exporters] → [category|SW 1.2.1.2.3|Export of peptides]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.13|Resistance against toxins/ antibiotics]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

Gene

Coordinates: 4,068,550 4,070,418

The protein

Protein family

• [SW|ABC-4 integral membrane protein family] (according to UniProt)

Paralogous protein(s)

• [protein|AC7F08DC1DF7DD2F9AFF84041D357B286B1244AC|PsdB]

[SW|Localization]

• cell membrane (according to UniProt)

Expression and Regulation

Operons

• genes: [gene|8B4267532B9788AEB5EF39E2695C1FDA494C7055|yxdL]-[gene|4423383A3F6DAFDFA210F4BEEF7D8CBEC674DCEA|yxdM]-[gene|6D9153BA698101C3EE1CD68B76419ECD300740F8|yxeA]
  description: [Pubmed|15289557]

  regulatory mechanism

  • [protein|F3C5505E311E6DDABAFA87899F28CF6596CDBA63|YxdJ]: activation, [Pubmed|15289557], in [regulon|F3C5505E311E6DDABAFA87899F28CF6596CDBA63|YxdJ regulon]

  regulation

  • induced by a cationic antimicrobial peptide, LL-37 ([protein|search|YxdJ]) [Pubmed| 21078927]

Biological materials

Mutant

• MGNA-B705 (yxdM::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1704 NBRP B. subtilis, Japan]
• BKE39630 ([gene|4423383A3F6DAFDFA210F4BEEF7D8CBEC674DCEA|yxdM]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE39630 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GGCCCTTTTGTTTCTCGTGA, downstream forward: _UP4_ATGAACAAGTAAGGGGAGTG
• BKK39630 ([gene|4423383A3F6DAFDFA210F4BEEF7D8CBEC674DCEA|yxdM]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK39630 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GGCCCTTTTGTTTCTCGTGA, downstream forward: _UP4_ATGAACAAGTAAGGGGAGTG

References

• 10092453,15289557,21283517