beta-ketoacyl-acyl carrier protein reductase
function
fatty acid biosynthesis
product
beta-ketoacyl-acyl carrier protein reductase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.2|Biosynthesis of lipids] → [category|SW 2.4.2.1|Biosynthesis of fatty acids][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][SW|Categories] containing this gene/protein
[SW|biosynthesis of lipids], [SW|essential genes]This gene is a member of the following [SW|regulons]
[SW|ComA regulon], [SW|FapR regulon]Gene
Coordinates on the chromosome (coding sequence)
1,664,513 -> 1,665,253
Phenotypes of a mutant
essential [Pubmed|12682299]The protein
Catalyzed reaction/ biological activity
(3R)-3-hydroxyacyl-[acyl-carrier-protein] NADP = 3-oxoacyl-[acyl-carrier-protein] NADPH (according to Swiss-Prot) Protein family
short-chain dehydrogenases/reductases (SDR) family (according to Swiss-Prot)Structure
[PDB|1I01] (the enzyme from ''E. coli'') [Pubmed|11669613]Expression and Regulation
Operon
''[protein|search|fapR]-[protein|search|plsX]-[protein|search|fabD]-[protein|search|fabG]-[protein|search|acpA]'' [Pubmed|12737802,19850612][SW|Sigma factor]
[protein|search|SigA] [Pubmed|16932747]Regulation
induced if the cells experience an accumulation of malonyl-CoA ([protein|search|FapR]) [Pubmed|12737802]expressed at high cell density ([protein|search|ComA]) [Pubmed|16091051]Regulatory mechanism
[protein|search|ComA]: transcription activation ([protein|search|ComA]) [Pubmed|16091051][protein|search|FapR]: transcription repression [Pubmed|12737802]References
Reviews
Original Publications
12737802,16932747,19850612,11669613,16091051 
