SubtiBank SubtiBank
pbuG [Mon Aug 31 2015 13:52:53 GMT+0200 (CEST)]
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pbuG [Mon Aug 31 2015 13:52:53 GMT+0200 (CEST)]

hypoxanthin/ guanine permease
locus
BSU06370
pI
8.81
mw
46.00 kDa
function
hypoxanthine and guanine uptake
product
hypoxanthin/ guanine permease
essential
no
synonyms
yebB

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.6|Nucleotide/ nucleoside transporter]
  • [category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.1|Biosynthesis/ acquisition of purine nucleotides]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • syns
    yebB

    [SW|Categories] containing this gene/protein

  • [SW|transporters/ other], [SW|biosynthesis/ acquisition of nucleotides], [SW|membrane proteins]
  • This gene is a member of the following [SW|regulons]

  • [SW|G-box], [SW|PurR regulon]
  • The protein

    Paralogous protein(s)

  • [protein|search|PbuO]
  • Structure

  • [PDB|2EEW] (the pbuG riboswitch, U47c mutant, bound to hypoxanthine)
  • [SW|Localization]

  • membrane [Pubmed|18763711]
  • Expression and Regulation

    Operon

  • ''pbuG'' [Pubmed|12923093]
  • Regulation

  • repressed by hypoxanthine and guanine, [protein|search|PurR]-independent, ([protein|search|G-box])[Pubmed|12923093]
  • repressed in the presence of adenine or adenosine([protein|search|PurR]) [Pubmed|2536750]
  • Regulatory mechanism

  • [protein|search|PurR]: transcription repression (molecular inducer: PRPP) [Pubmed|2536750]
  • [protein|search|G-box]: transcription termination/ antitermination ([SW|riboswitch]) [Pubmed|12923093]
  • References

  • 11591660,12923093,11591660,18763711,12923093,12787499