ltaS [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]

major polyglycerolphosphate lipoteichoic acid synthase

locus: BSU07710

pI: 5.00

mw: 74.00 kDa

function: biosynthesis of lipoteichoic acid

product: major lipoteichoic acid synthase

essential: no

ec: 2.7.8.-

synonyms: yflE

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.3|Biosynthesis of lipoteichoic acid]
• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.1|Biosynthesis of cell wall components] → [category|SW 2.6.1.2|Biosynthesis of lipoteichoic acid]
• [category|SW 6|Groups of genes] → [category|SW 6.12|Secreted proteins]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
• [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.6|Phosphorylation on a Thr residue]

[SW|Categories] containing this gene/protein

• [SW|cell wall synthesis], [SW|biosynthesis of cell wall components], [SW|membrane proteins], [SW|phosphoproteins]

Gene

Coordinates on the chromosome (coding sequence): 842,047 -> 843,996

Phenotypes of a mutant

• induction of [protein|search|SigM] and [protein|search|SigX] activities [Pubmed|23103977]
• reduced [protein|search|SigD]-dependent expression of ''[protein|search|lytF]'' [Pubmed|25288647]

The protein

Protein family

• LTA synthase family (according to Swiss-Prot)

Paralogous protein(s)

• [protein|search|YfnI], [protein|search|YqgS], [protein|search|YvgJ]

Modification

• phosphorylated on Thr-297 [Pubmed|19229300]

Structure

• [http://www.ncbi.nlm.nih.gov/Structure/mmdb/mmdbsrv.cgi?Dopt=s&uid=69910&ordinalpos=1&log$=structuread_title 2W8D]

[SW|Localization]

• cell membrane, at the septum of the cell [Pubmed|15743965]
• extracellular (signal peptide) [Pubmed|18957862]

Expression and Regulation

Operon

• ''ltaS'' (according to [http://dbtbs.hgc.jp/COG/prom/yflE.html DBTBS])

Biological materials

Mutant

• GP1389 ''ltaS::aphA3'', available in [SW|Jörg Stülke]'s lab
• GP1396 ''ltaS::tet'', available in [SW|Jörg Stülke]'s lab

References

Reviews

• 21388439,21255102,24819367

Original publications

• 19229300,17483484,21255105,19168632,15743965,23103977,25288647