SubtiBank SubtiBank
pyrH [Mon Aug 31 2015 13:54:21 GMT+0200 (CEST)]
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pyrH [Mon Aug 31 2015 13:54:21 GMT+0200 (CEST)]

uridylate kinase
locus
BSU16510
pI
5.00
mw
25.00 kDa
function
pyrimidine biosynthesis
product
uridylate kinase
essential
no
ec
2.7.4.22
synonyms
smbA

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.4|Biosynthesis/ acquisition of pyrimidine nucleotides]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis/ acquisition of nucleotides]
  • This gene is a member of the following [SW|regulons]

  • [SW|stringent response]
  • Gene

    Coordinates on the chromosome (coding sequence)
    1,719,802 -> 1,720,524

    The protein

    Catalyzed reaction/ biological activity

  • ATP UMP = ADP UDP (according to Swiss-Prot)
  • Protein family

  • UMP kinase family (according to Swiss-Prot)
  • Structure

  • [PDB|2JJX] (from ''Bacillus anthracis'', 42% identity, 64% similarity) [Pubmed|18625239]
  • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)
  • Expression and Regulation

    Regulation

  • [protein|search|RelA] dependent downregulation (Class I) during stringent response [Pubmed|11948165]
  • References

  • 12869195,8206849,1709162