SubtiBank SubtiBank
valS
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valS

valyl-tRNA synthetase
locus
BSU28090
pI
4.87
mw
101.55 kDa
protein length
880 aa Sequence Blast
gene length
2640 bp Sequence Blast
function
translation
product
valyl-tRNA synthetase
essential
yes
ec
6.1.1.9
synonyms

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.10|Aminoacyl-tRNA synthetases]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [category|SW 6|Groups of genes] → [category|SW 6.11|Efp-dependent proteins]
  • Gene

    Coordinates
    2,866,664 → 2,869,306

    Phenotypes of a mutant

  • essential [Pubmed|12682299]
  • The protein

    Catalyzed reaction/ biological activity

  • ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val) (according to Swiss-Prot)
  • Protein family

  • ValS type 1 subfamily (according to Swiss-Prot)
  • Structure

  • [PDB|1IYW] (from ''Thermus thermophilus'', 41% identity, 60% similarity) [Pubmed|12554880]
  • additional information

  • belongs to the 100 [SW|most abundant proteins] [PubMed|15378759]
  • Expression and Regulation

    Operons

    genes
    [gene|3E84B3AC08D0B314286CEF38534BD81B568F3E0E|valS]-[gene|80502F76F076C08CCE702F25095C06D14CD8154A|folC]
    description
    [Pubmed|9098041]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|9098041], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]
  • regulatory mechanism

  • [regulon|T-box|T-box]: transcription termination/antitermination, via [SW|riboswitch], in [regulon|T-box|T-box]
  • regulation

  • induced by valine limitation ([SW|T-box]) [Pubmed|9098041,19258532]
  • the [SW|T-box] RNA is degraded by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] [pubmed|29794222]
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    additional information

  • [protein|search|translation] is likely to require [protein|3054CD45713BBD69C2A528DE24AF6AF37175FD9D|Efp] due to the presence of several consecutive proline residues [PubMed|23239624,23239623]
  • References

    Reviews

  • 19258532
  • Original Publications

  • 9098041,15378759,25310979,29794222