SubtiBank SubtiBank
fhuB
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fhuB

hydroxamate siderophore [SW|ABC transporter] (ferrichrome und ferrioxamine) (permease)
locus
BSU_33310
pI
10.14
mw
40.56 kDa
protein length
384 aa Sequence Blast
gene length
1155 bp Sequence Blast
function
siderophore uptake
product
hydroxamate siderophore [SW|ABC transporter ](ferrichrome und ferrioxamine) (permease)
essential
no
synonyms

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.1|Importers] → [category|SW 1.2.1.1.5|Uptake of iron/ siderophores]
  • [category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.3|Acquisition of iron] → [category|SW 1.3.3.1|ABC transporters for the uptake of iron/ siderophores]
  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.5|Iron metabolism] → [category|SW 2.6.5.4|ABC transporters for the uptake of iron/ siderophores]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • Gene

    Coordinates
    3,417,222 3,418,376

    The protein

    Protein family

  • [SW|Binding-protein-dependent transport system permease family] (according to UniProt)
  • [SW|FecCD subfamily] (according to UniProt)
  • Paralogous protein(s)

  • [protein|57402D137E3D3791CAF0696421224F4E1DC1BA48|FeuB], [protein|81494D4E7E52531802C3C0D0073739DA9375F5DF|YfiZ], [protein|BDAA56484E05DA3C1CB0CA09873A365657999679|FecD]
  • Structure

  • [PDB|4G1U] (from Yersinia pestis, 37% identity) [pubmed|23142986]
  • [SW|Localization]

  • cell membrane (according to UniProt)
  • Expression and Regulation

    Operons

    genes
    [gene|3E1C925C31C00803982C8EB1C6B025C22DB4A828|fhuB]-[gene|EC98685EE0E3CE6CE8DC33409481AE96315279AC|fhuG]-[gene|E70BE74D5AB4B06CDFF902E58A0B9EBF477E21EC|fhuC]

    description

  • [pubmed|22383849]
  • regulatory mechanism

  • [protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|Fur]: repression, [pubmed|12354229], in [regulon|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|Fur regulon]
  • regulation

  • induced by iron starvation (second wave to allow iron scavenging from the environment) ([protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|Fur]) [pubmed|29133393,12354229]
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    Biological materials

    Mutant

  • BKE33310 ([gene|3E1C925C31C00803982C8EB1C6B025C22DB4A828|fhuB]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE33310 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTGCAAAAATATCGTGT, downstream forward: _UP4_CGTCGTGAAAGGAGAGGGCT
  • BKK33310 ([gene|3E1C925C31C00803982C8EB1C6B025C22DB4A828|fhuB]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK33310 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTGCAAAAATATCGTGT, downstream forward: _UP4_CGTCGTGAAAGGAGAGGGCT
  • References

  • 10092453,16672620,12354229,23142986,29133393