ribD [Sun Oct 25 2015 18:15:09 GMT+0100 (CET)]

5-amino-6-(5-phosphoribosylamino)uracil reductase

locus: BSU23280

pI: 6.00

mw: 39.00 kDa

function: riboflavin biosynthesis

product: 5-amino-6-(5-phosphoribosylamino)uracil reductase

essential: no

ec: 3.5.4.26

synonyms: ribG

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.2|Biosynthesis/ acquisition of riboflavin/ FAD]

[SW|Categories] containing this gene/protein

• [SW|biosynthesis of cofactors]

This gene is a member of the following [SW|regulons]

• [SW|FMN-box]

The protein

Catalyzed reaction/ biological activity

• 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine H₂O = 5-amino-6-(5-phosphoribosylamino)uracil NH₃ (according to Swiss-Prot)

Structure

• [PDB|3EX8] [Pubmed|18986985]

Expression and Regulation

Operon

• ''[protein|search|ribD]-[protein|search|ribE]-[protein|search|ribA]-[protein|search|ribH]-[protein|search|ribT]'' [Pubmed|8159171]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|8159171]

Regulation

• expressed in the absence of FMN ([protein|search|FMN-box]) [Pubmed|15808508]

Regulatory mechanism

• [protein|search|FMN-box]: [SW|riboswitch], mediates termination of transcription in the presence of FMN or FMNH₂, this is counter-acted upon binding of [SW|RibR] [Pubmed|26494285][Pubmed|15808508]

References

• 12456892,15808508,18986985,8159171,7934830,23270261