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fatR [Tue Dec 13 2016 11:16:35 GMT+0100 (CET)]
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fatR [Tue Dec 13 2016 11:16:35 GMT+0100 (CET)]

transcriptional repressor of the fatR-yrhJ operon
locus
BSU27170
pI
5.62
mw
22.00 kDa
function
unknown
product
transcriptional repressor
of the fatR-yrhJ operon (TetR family)
essential
no
synonyms
yrhI, bscR
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.1|Electron transport and ATP synthesis] → [category|SW 2.1.3|Electron transport/ other]
  • [category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.3|Lipid metabolism/ other]
  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.2|Cell envelope stress proteins (controlled by SigM, V, W, X, Y)]

    • [SW|Categories] containing this gene/protein

  • [SW|electron transport/ other], [SW|lipid metabolism/ other], [SW|transcription factors and their control], [SW|cell envelope stress proteins (controlled by SigM, V, W, X, Y)], [SW|phosphoproteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|FatR regulon], [SW|SigM regulon], [SW|SigW regulon], [SW|SigX regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    2,777,070 -> 2,777,654

    The protein

    Modification

  • phosphorylated by [protein|search|PtkA] on Tyr-45, this results in displacement of FatR from the DNA [Pubmed|23939619]

    • [SW|Interactions]

  • [protein|search|FatR]-[protein|search|TkmA] [Pubmed|23939619]
  • [protein|search|FatR]-[protein|search|PtkA] [Pubmed|23939619]

    • Expression and Regulation

    Operon

  • ''[protein|search|fatR]-[protein|search|yrhJ]'' [Pubmed|10917605]
  • ''[protein|search|yrhH]-[protein|search|fatR]-[protein|search|yrhJ]'' [Pubmed|18179421]

    • [SW|Sigma factor]

  • [protein|search|SigM] [Pubmed|18179421], [protein|search|SigW] [Pubmed|12207695], [protein|search|SigX] [Pubmed|9636707]

    • Regulation

  • induced by unsaturated fatty acids ([protein|search|FatR]) [Pubmed|11734890]
  • expression is reduced in a [protein|search|SigV] mutant [Pubmed|21926231]

    • Regulatory mechanism

  • [protein|search|FatR]: transcription repression [Pubmed|11734890]

    • References

  • 11734890,11574077,11377867,10917605,12207695,9636707,23939619,21926231