type IV apurinic/apyrimidinic endonuclease
function
repair of oxidative DNA damage in spores
product
type IV apurinic/apyrimidinic endonuclease
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination][category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination] → [category|SW 3.1.5.2|A/P endonucleases][SW|Categories] containing this gene/protein
[SW|DNA repair/ recombination], [SW|sporulation proteins]This gene is a member of the following [SW|regulons]
[SW|SigG regulon]Gene
Coordinates on the chromosome (coding sequence)
2,593,281 -> 2,594,174
Phenotypes of a mutant
an ''[protein|search|exoA] [protein|search|nfo]'' double mutant is impaired in germination and spore outgrowth due to the accumulation of DNA lesions, this can be rescued by inactivation of ''[protein|search|disA]'' [Pubmed|24244006]an ''[protein|search|exoA] [protein|search|nfo]'' double mutant is sensitive to radiation [Pubmed|24123749]The protein
Catalyzed reaction/ biological activity
Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products (according to Swiss-Prot)Protein family
AP endonuclease 2 family (according to Swiss-Prot)Expression and Regulation
Operon
''[protein|search|nfo]-[protein|search|yqfU]'' [Pubmed|12486072][SW|Sigma factor]
[protein|search|SigG] [Pubmed|12486072]Regulation
expressed late during sporulation in the forespore ([protein|search|SigG]) [Pubmed|12486072]Additional information
The gene '[protein|search|yqfT]' is located between '[protein|search|nfo]' and '[protein|search|yqfU]', but is transcribed in the opposite direction.Biological materials
Mutant
available in [[Mario Pedraza-Reyes]]' labGP899 (''nfo''::''kan'') and GP1502 (''nfo''::''cat''), available in [SW|Stülke] labReferences
Reviews
Original publications
24244006,18203828,16237020,12949090,19930460,12486072,21441501,24123749,24123749,24914186 
