murC

UDP-N-acetylmuramoyl-L-alanine synthetase

locus: BSU_29790

pI: 5.31

mw: 48.20 kDa

protein length: 432 aa

gene length: 1299 bp

function: peptidoglycan precursor biosynthesis

product: UDP-N-acetylmuramoyl-L-alanine synthetase

essential: yes

ec: 6.3.2.8

synonyms: ytxF

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.1|Biosynthesis of peptidoglycan]
• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.1|Biosynthesis of cell wall components] → [category|SW 2.6.1.1|Biosynthesis of peptidoglycan]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

Gene

Coordinates: 3,048,177 3,049,475

Phenotypes of a mutant

• essential [Pubmed|12682299]
• murC is dispensable in wall-less L-forms [Pubmed|24704074]

The protein

Catalyzed reaction/ biological activity

• ATP + L-alanine + UDP-N-acetyl-α-D-muramate --> ADP + H⁺ + phosphate + UDP-N-acetyl-α-D-muramoyl-L-alanine (according to UniProt)

Protein family

• [SW|MurCDEF family] (according to UniProt)

Structure

• [PDB|1GQQ] (from Haemophilus influenzae, 31% identity)

[SW|Localization]

• cytoplasm (Homogeneous) [Pubmed|16479537]
• forms banded patterns along the length of the cell, this pattern formation depends on [protein|A4C8719E06F774A6EB4D79757CC79CF89E453A54|MreB] [Pubmed|20233306]

Expression and Regulation

Operons

• genes: [gene|3BF530AB1B6A3DB3671FC046E2B38CA1936E6F78|murC]
  description: [Pubmed|8733232]

• genes: [gene|DF77B46666595E86081C5345C91E08F86DF9FAEE|sftA]-[gene|3BF530AB1B6A3DB3671FC046E2B38CA1936E6F78|murC]
  description: [Pubmed|22383849]

References

• 18063720,8733232,24704074,16479537,20233306