elemental iron uptake system, heme peroxidase, converts ferrous iron (Fe(II) to ferric iron (FeIII)) for uptake by EfeO-EfeU, peroxide detoxification under microaerobic conditions
function
ferrous iron conversion
product
heme peroxidase in elemental iron uptake
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.3|Acquisition of iron] → [category|SW 1.3.3.2|Elemental iron transport system][category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.5|Iron metabolism] → [category|SW 2.6.5.5|Elemental iron transport system][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.2|Cell envelope stress proteins (controlled by SigM, V, W, X, Y)][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress][category|SW 6|Groups of genes] → [category|SW 6.12|Secreted proteins][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|acquisition of iron], [SW|iron metabolism], [SW|cell envelope stress proteins (controlled by SigM, V, W, X, Y)], [SW|resistance against oxidative and electrophile stress], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|Fur regulon], [SW|SigM regulon], [SW|SigW regulon], [SW|SigX regulon]Gene
Coordinates on the chromosome (coding sequence)
3,926,682 -> 3,927,932
The protein
Catalyzed reaction/ biological activity
oxidizes ferrous iron to ferric iron for uptake by [protein|search|EfeO]-[protein|search|EfeU] [Pubmed|23764491]eliminates reactive oxygen species that accumulate in the presence of ferrous iron [Pubmed|23764491]peroxide detoxification under microaerobic conditions [Pubmed|23764491]Protein family
DyP-type peroxidase family (according to Swiss-Prot)[SW|Cofactors]
protoheme IX [Pubmed|23764491]Effectors of protein activity
activity is increased in the presence of [protein|search|EfeO] due to the displacement of ferric iron [Pubmed|23764491]Structure
[PDB|2Y4F] (from ''E. coli'', 38% identity)[SW|Localization]
extracellular, secreted by the [SW|TatAY]-[SW|TatCY] complex [Pubmed|15554971][SW|TatAY]-[SW|TatCY]-dependent export of [protein|search|EfeB] requires a functional [protein|search|WprA] [Pubmed|23180473]forms a membrane-bound complex with [protein|search|EfeU] and [protein|search|EfeO] for iron uptake [Pubmed|23180473,23764491]attached to the membrane via [protein|search|EfeU] [Pubmed|23764491][SW|Interactions]
[protein|search|EfeO]-[protein|search|EfeU]-[protein|search|EfeB] [Pubmed|23180473,23764491]Expression and Regulation
Operon
''[protein|search|efeU]-[protein|search|efeO]-[protein|search|efeB]'' [Pubmed|9353933]''[protein|search|efeB]-[protein|search|ywbO]'' [Pubmed|18179421][SW|Sigma factor]
''[protein|search|efeU]'': [protein|search|SigA] [Pubmed|23764491]''[protein|search|efeB]'': [protein|search|SigM] [Pubmed|18179421], [protein|search|SigX], [protein|search|SigW] [Pubmed|9683469]Regulation
induced upon iron starvation ([protein|search|Fur]) [Pubmed|12354229]Regulatory mechanism
[protein|search|Fur]: transcription repression [Pubmed|12354229]Labs working on this gene/protein
[SW|Jan Maarten van Dijl], Groningen, NetherlandsReferences
Reviews
Original publications
16672620,19180538,12354229,19383693,9353933,9683469,15554971,21479178,18179421,22923395,23180473,23560556,23764491,23820555,24620988,18931290,26239117,27795321 
