SubtiBank SubtiBank
msrA [Tue Dec 13 2016 11:16:34 GMT+0100 (CET)]
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msrA [Tue Dec 13 2016 11:16:34 GMT+0100 (CET)]

peptide methionine sulfoxide reductase
locus
BSU21690
pI
5.71
mw
20.00 kDa
function
regeneration of methionine and restoration
of protein function after oxidative damage
product
peptide methionine sulfoxide reductase
essential
no
ec
1.8.4.11
synonyms
yppP
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress]

    • [SW|Categories] containing this gene/protein

  • [SW|resistance against oxidative and electrophile stress]

    • This gene is a member of the following [SW|regulons]

  • [SW|Spx regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    2,287,529 -> 2,288,062

    The protein

    Catalyzed reaction/ biological activity

  • Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin (according to Swiss-Prot)

    • Expression and Regulation

    Operon

  • ''[protein|search|msrA]-[protein|search|msrB]'' [Pubmed|18662407]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|18662407]

    • Regulation

  • induced by oxidative stress ([protein|search|Spx])

    • Regulatory mechanism

  • Spx: oxidized Spx binds [protein|search|RpoA] and enhances ''[protein|search|msrA]-[protein|search|msrB]'' operon transcription [Pubmed|18662407]

    • References

  • 18662407