cell-division inhibitor (septum placement), part of the Min system (with Z ring placement
function
septum placement
product
cell-division inhibitor
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.8|Cell division] → [category|SW 1.1.8.1|The Min system][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.2|Cell envelope stress proteins (controlled by SigM, V, W, X, Y)][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|cell division], [SW|cell envelope stress proteins (controlled by SigM, V, W, X, Y)], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|SigH regulon], [SW|SigM regulon], [SW|ComK regulon]Gene
Coordinates on the chromosome (coding sequence)
2,857,776 -> 2,858,582
Phenotypes of a mutant
a ''[protein|search|yvcL] [protein|search|minC]-[protein|search|minD]'' mutant grows poorly, and the cells are filamentous [Pubmed|24097947]The protein
Catalyzed reaction/ biological activity
The Min system prevents minicell formation adjacent to recently completed division sites by promoting the disassembly of the cytokinetic ring, thereby ensuring that cell division occurs only once per cell cycle [Pubmed|20352045]Protein family
MinD subfamily (according to Swiss-Prot)Structure
[PDB|4V03] (from ''Aquifex aeolicus'', 51% identity) [Pubmed|25500731][SW|Localization]
polar/ septal at the cell membrane [Pubmed|20566861]membrane binding/ polar localization depends on the proton motive force [Pubmed|20566861][SW|Interactions]
([protein|search|MinC]-[protein|search|MinD])-[protein|search|MinJ]-[SW|DivIVA] [Pubmed|20352045]Expression and Regulation
Operon
''[protein|search|maf]-[protein|search|radC]-[protein|search|mreB]-[protein|search|mreC]-[protein|search|mreD]-[protein|search|minC]-[protein|search|minD]'' [Pubmed|22383849]''[protein|search|mreB]-[protein|search|mreC]-[protein|search|mreD]-[protein|search|minC]-[protein|search|minD]'' [Pubmed|8459776]''[protein|search|minC]-[protein|search|minD]'' [Pubmed|8459776][SW|Sigma factor]
promoter p1 (upstream of ''[protein|search|maf]''): [SW|SigA] [Pubmed|26091431]promoter p2 (within ''[protein|search|maf]''): [SW|SigM] [Pubmed|18179421]promoter p3 (upstream of ''[protein|search|mreB]''): [SW|SigA] [Pubmed|26091431]promoter p4 (upstream of ''[protein|search|minC]''): [SW|SigH] [Pubmed|8459776]Regulation
expression is reduced in a [protein|search|SigV] mutant [Pubmed|21926231]constitutively expressed [Pubmed|23701187]promoter p3 (upstream of ''[protein|search|mreB]''): expressed during the development of genetic competence ([SW|ComK]) [Pubmed|26091431]Regulatory mechanism
[SW|ComK]: transcription activation [Pubmed|26091431]Biological materials
two-hybrid system
''B. pertussis'' adenylate cyclase-based bacterial two hybrid system ([SW|BACTH]), available in [SW|Jörg Stülke]'s labReferences
Reviews
26286503,19884039,24367361 Original Publications
8459776,19019154,11886553,9808628,1400224,12368265,10411726,15317782,12492861,20352045,11886553,20566861,18179421,21821766,22457634,21926231,24097947,25374563,25500731,22383849,26091431 
