tcdA [Tue Dec 13 2016 11:16:35 GMT+0100 (CET)]

2-methylthio-N6-threonylcarbamoyladenosine cyclase, catalyzes ATP-dependent dehydration of 2-methylthio N6-threonylcarbamoyladenosine (t6A) to form 2-methylthio cyclic N6-threonylcarbamoyladenosine (ms2ct6A )

locus: BSU27540

pI: 8.00

mw: 28.00 kDa

function: tRNA modification

product: 2-methylthio-N6-threonylcarbamoyladenosine cyclase

essential: no

synonyms: yrvM

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.8|tRNA modification and maturation]

[SW|Categories] containing this gene/protein

• [SW|translation]

Gene

Coordinates on the chromosome (coding sequence): 2,813,643 -> 2,814,407

The protein

Catalyzed reaction/ biological activity

• catalyzes ATP-dependent dehydration of 2-methylthio N6-threonylcarbamoyladenosine (t6A) to form 2-methylthio cyclic N6-threonylcarbamoyladenosine (ms2ct6A ) [Pubmed|27913733,23242255]

Structure

• [PDB|4D7A] (from ''E. coli'', 40% identity) [Pubmed|25897750]

References

• 23242255,27913733,25897750