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hpf [Tue Feb 23 2016 17:37:13 GMT+0100 (CET)]
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hpf [Tue Feb 23 2016 17:37:13 GMT+0100 (CET)]

general stress protein, required for ribosome dimerization in the stationary phase, required for protection against paraquat stress
locus
BSU35310
pI
5.00
mw
21.00 kDa
function
dimerization of ribosomes in the stationary phase, protection against paraquat stress
product
ribosome hibernation promoting factor
essential
no
synonyms
yviI,yvyD
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.1|General stress proteins (controlled by SigB)]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.1|Phosphorylation on an Arg residue]

    • [SW|Categories] containing this gene/protein

  • [SW|general stress proteins (controlled by SigB)], [SW|resistance against oxidative and electrophile stress], [SW|membrane proteins], [SW|phosphoproteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|PhoP regulon], [SW|SigB regulon], [SW|SigH regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    3,631,003 -> 3,631,572

    Phenotypes of a mutant

  • the mutant is cold-sensitive
  • delayed recovery from stationary phase and delayed [SW|germination] [Pubmed|26743942]

    • The protein

    Catalyzed reaction/ biological activity

  • binds during stationary phase to the [SW|ribosome] and promotes [SW|ribosome] dimerization [Pubmed|26743942]

    • Protein family

  • ribosomal protein S30Ae family (according to Swiss-Prot)

    • Modification

  • phosphorylated on Arg-6 [Pubmed|22517742]

    • [SW|Localization]

  • membrane protein

    • [SW|Interactions]

  • [protein|search|YvyD]-[SW|ribosome] (for ribosome dimerization) [Pubmed|22950019]

    • Expression and Regulation

    Operon

  • ''yvyD'' [Pubmed|9852014]

    • [SW|Sigma factor]

  • [protein|search|SigB] [Pubmed|9852014,15805528], [protein|search|SigH] [Pubmed|9852014]

    • Regulation

  • expressed in the stationary phase [Pubmed|26743942]
  • repressed by casamino acids [Pubmed|12107147]
  • induced by stress ([protein|search|SigB]) [Pubmed|15805528]
  • induced under conditions of phosphate limitation ([protein|search|PhoP]) [Pubmed|25666134]

    • Regulatory mechanism

  • [protein|search|PhoP]: transcription activation [Pubmed|25666134]

    • References

  • 22517742,26743942,9852014,15805528,25666134,12107147,23663662