SubtiBank SubtiBank
infB [Mon Aug 31 2015 13:54:21 GMT+0200 (CEST)]
SAVE THE DATE! 21st International Conference on Bacilli and Gram-Positive Bacteria. Prague, Czech Republic, June 7-11, 2021.

infB [Mon Aug 31 2015 13:54:21 GMT+0200 (CEST)]

translation initiation factor IF-2
locus
BSU16630
pI
5.19
mw
78.00 kDa
function
translation
product
initiation factor IF-2
essential
yes
synonyms

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.11|Translation factors]
  • [category|SW 3|Information processing] → [category|SW 3.5|Targets of second messengers] → [category|SW 3.5.3|Targets of (p)ppGpp]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [SW|Categories] containing this gene/protein

  • [SW|translation], [SW|essential genes]
  • This gene is a member of the following [SW|regulons]

  • [SW|stringent response]
  • Gene

    Phenotypes of a mutant

  • essential [Pubmed|12682299]
  • The protein

    Catalyzed reaction/ biological activity

  • Initiation of translation
  • Protein family

  • IF-2 family (according to Swiss-Prot)
  • [SW|Domains]

  • Nucleotide-binding domain that competitively binds GTP or ppGpp [Pubmed|16968770]
  • Effectors of protein activity

  • GTP and ppGpp [Pubmed|16968770]
  • Structure

  • [PDB|1D1N] (fMet-tRNA-fMet binding domain, Geobacillus stearothermophilus), [PDB|1Z9B] (C1-subdomain, Geobacillus stearothermophilus)
  • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)
  • Expression and Regulation

    Operon

  • ''[protein|search|ylxS]-[protein|search|nusA]-[protein|search|ylxR]-[protein|search|ylxQ]-[protein|search|infB]-[protein|search|ylxP]-[protein|search|rbfA]'' [Pubmed|8491709]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|8491709]
  • Regulation

  • [protein|search|RelA] dependent downregulation (Class I) during stringent response [Pubmed|11948165]
  • Interaction with ppGpp interferes with IF2-dependent initiation complex formation, severely inhibits initiation dipeptide formation, and blocks the initiation step of translation.[Pubmed|16968770]
  • References

  • 11948165,8491709,16968770