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prs [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]
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prs [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]

phosphoribosylpyrophosphate synthetase, universally conserved protein
locus
BSU00510
pI
5.00
mw
34.00 kDa
function
phosphoribosylpyrophosphate synthesis
(biosynthesis of histidine)
product
phosphoribosylpyrophosphate synthetase
essential
yes
ec
2.7.6.1
synonyms

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.14|Biosynthesis/ acquisition of histidine]
  • [category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.1|Biosynthesis/ acquisition of purine nucleotides]
  • [category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.4|Biosynthesis/ acquisition of pyrimidine nucleotides]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [category|SW 6|Groups of genes] → [category|SW 6.5|Universally conserved proteins]
  • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis/ acquisition of amino acids], [SW|biosynthesis/ acquisition of nucleotides], [SW|essential genes], [SW|universally conserved proteins]
  • This gene is a member of the following [SW|regulons]

  • [SW|stringent response]
  • Gene

    Coordinates on the chromosome (coding sequence)
    57,745 -> 58,698

    Phenotypes of a mutant

  • essential [Pubmed|12682299]
  • The protein

    Catalyzed reaction/ biological activity

  • ATP D-ribose 5-phosphate = AMP 5-phospho-alpha-D-ribose 1-diphosphate (according to Swiss-Prot)
  • Protein family

  • ribose-phosphate pyrophosphokinase family (according to Swiss-Prot)
  • Effectors of protein activity

  • subject to feedback inhibition by two end products of purine biosynthesis, adenosine 5'-diphosphate (ADP) and guanosine 5'-diphosphate (GDP) [Pubmed|22083279]
  • Structure

  • [PDB|1IBS] [PDB|1DKR][PDB|1DKU]
  • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)
  • [SW|Interactions]

  • [protein|search|PurR]-[protein|search|Prs]
  • Additional information

  • [SW|universally conserved protein]
  • Expression and Regulation

    Operon

  • ''[protein|search|gcaD]-[protein|search|prs]-[protein|search|ctc]'' [Pubmed|8522540]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|8522540]
  • Regulation

  • [protein|search|RelA] dependent downregulation (Class I) during stringent response [Pubmed|11948165]
  • References

  • 2169413,8522540,12837783,12837784,19446032,22083279