SubtiBank SubtiBank
sigA [Fri Jan 29 2016 15:57:31 GMT+0100 (CET)]
You are currently viewing an outdated version of SubtiWiki. Please use the newest version!

sigA [Fri Jan 29 2016 15:57:31 GMT+0100 (CET)]

RNA polymerase major sigma factor SigA
locus
BSU25200
pI
4.00
mw
42.00 kDa
function
transcription
product
RNA polymerase major sigma factor SigA
essential
yes
synonyms
rpoD, crsA

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.2|RNA synthesis and degradation] → [category|SW 3.2.1|Transcription] → [category|SW 3.2.1.2|Sigma factors]
  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.1|Sigma factors and their control] → [category|SW 3.4.1.1|Sigma factors]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.1|Phosphorylation on an Arg residue]
  • [SW|Categories] containing this gene/protein

  • [SW|transcription], [SW|sigma factors and their control], [SW|essential genes]
  • This gene is a member of the following [SW|regulons]

  • [SW|SigD regulon], [SW|SigH regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    2,600,214 -> 2,601,329

    Phenotypes of a mutant

  • essential [Pubmed|12682299]
  • The protein

    Protein family

  • sigma-70 factor family (according to Swiss-Prot)
  • Structure

  • [PDB|3IYD] ([SW|RNA polymerase] from ''E. coli'', 69% identity) [Pubmed|19903881]
  • [SW|Localization]

  • cytoplasm [Pubmed|25313396]
  • [SW|Interactions]

  • [SW|Spo0A]-[protein|search|SigA] [Pubmed|14976210]
  • [protein|search|SigA]-([protein|search|RpoB]-[protein|search|RpoC]) [Pubmed|19680289,19735077]
  • [protein|search|BsrA]-[protein|search|SigA]-[SW|RNA polymerase]
  • [protein|search|BsrB]-[protein|search|SigA]-[SW|RNA polymerase]
  • [SW|ComA]-[SW|SigA] [Pubmed|26582911]
  • Expression and Regulation

    Operon

  • ''[protein|search|yqxD]-[protein|search|dnaG]-[protein|search|sigA]'' [Pubmed|3298998]
  • ''[protein|search|sigA]'' [Pubmed|3919021]
  • [SW|Sigma factor]

  • ''[protein|search|yqxD]'': [protein|search|SigA] [Pubmed|3298998], [protein|search|SigH] [Pubmed|3127379]
  • ''[protein|search|sigA]'': [protein|search|SigD] [Pubmed|3919021]
  • Additional information

  • An [ncRNA|search|antisense RNA] is predicted for '[protein|search|sigA]' [PubMed|20525796]
  • Labs working on this gene/protein

  • [SW|Charles Moran], Emory University, NC, USA [http://www.microbiology.emory.edu/moran_c.html homepage]
  • References

    Reviews

  • 22210308,24308327
  • Original publications

  • 12486038,10556308,8107087,14762002,7918363,8071196,7630711,9185571,9287022,14679239,14976210,19735077,2997585,9658000,3127379,10438769,11535782,7599136,9144176,19680289,20525796,22333917,20935043,20817769,23875654,25112476,26582911,19903881