sigA [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]

RNA polymerase major sigma factor SigA

locus: BSU25200

pI: 4.00

mw: 42.00 kDa

function: transcription

product: RNA polymerase major sigma factor SigA

essential: yes

synonyms: rpoD, crsA

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.2|RNA synthesis and degradation] → [category|SW 3.2.1|Transcription] → [category|SW 3.2.1.2|Sigma factors]
• [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.1|Sigma factors and their control] → [category|SW 3.4.1.1|Sigma factors]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
• [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.1|Phosphorylation on an Arg residue]

[SW|Categories] containing this gene/protein

• [SW|transcription], [SW|sigma factors and their control], [SW|essential genes]

This gene is a member of the following [SW|regulons]

• [SW|SigD regulon], [SW|SigH regulon]

Gene

Coordinates on the chromosome (coding sequence): 2,600,214 -> 2,601,329

Phenotypes of a mutant

• essential [Pubmed|12682299]

The protein

Protein family

• sigma-70 factor family (according to Swiss-Prot)

[SW|Localization]

• cytoplasm [Pubmed|25313396]

[SW|Interactions]

• [SW|Spo0A]-[protein|search|SigA] [Pubmed|14976210]
• [protein|search|SigA]-([protein|search|RpoB]-[protein|search|RpoC]) [Pubmed|19680289,19735077]
• [protein|search|BsrA]-[protein|search|SigA]-[SW|RNA polymerase]
• [protein|search|BsrB]-[protein|search|SigA]-[SW|RNA polymerase]
• [SW|ComA]-[SW|SigA] [Pubmed|26582911]

Expression and Regulation

Operon

• ''[protein|search|yqxD]-[protein|search|dnaG]-[protein|search|sigA]'' [Pubmed|3298998]
• ''[protein|search|sigA]'' [Pubmed|3919021]

[SW|Sigma factor]

• ''[protein|search|yqxD]'': [protein|search|SigA] [Pubmed|3298998], [protein|search|SigH] [Pubmed|3127379]
• ''[protein|search|sigA]'': [protein|search|SigD] [Pubmed|3919021]

Additional information

• An [ncRNA|search|antisense RNA] is predicted for '[protein|search|sigA]' [PubMed|20525796]

Labs working on this gene/protein

• [SW|Charles Moran], Emory University, NC, USA [http://www.microbiology.emory.edu/moran_c.html homepage]

References

Reviews

• 22210308,24308327

Original publications

• 12486038,10556308,8107087,14762002,7918363,8071196,7630711,9185571,9287022,14679239,14976210,19735077,2997585,9658000,3127379,10438769,11535782,7599136,9144176,19680289,20525796,22333917,20935043,20817769,23875654,25112476,26582911