function
regulation of tryptophan biosynthesis
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.13|Biosynthesis/ acquisition of aromatic amino acids][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.7|Control of transcription factor (other than two-component system)][SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of amino acids], [SW|transcription factors and their control]This gene is a member of the following [SW|regulons]
[SW|T-box]The protein
Structure
[PDB|1N53] (structure of T box RNA), [PDB|2BX9], [PDB|2ZP9] (complex with [protein|search|MtrB])[SW|Localization]
cytoplasm (according to Swiss-Prot)[SW|Interactions]
[MtrB|search|TRAP]11-[protein|search|RtpA]3 [Pubmed|24682818,11557884]forms trimers and dodecamers (tetramer of trimers) [Pubmed|20713740], only the trimeric form interacts with [MtrB|search|TRAP] [Pubmed|20713740]Expression and Regulation
Operon
''[protein|search|rtpA]-[protein|search|ycbK]'' [Pubmed|10706627][SW|Sigma factor]
[protein|search|SigA] [Pubmed|10706627]Regulation
induced by tryptophan limitation ([protein|search|T-box] in the mRNA leader, [MtrB|search|TRAP]) [Pubmed|10706627]Regulatory mechanism
[protein|search|T-box], [MtrB|search|TRAP]: transcription termination/ antitermination [Pubmed|10706627]References
Reviews
Original Publications
15213402,16306262,15099736,15743934,11786553,11566976,15023340,18178730,12386162,11557884,10706627,18334255,12855807,20713740,24682818 
