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mtnB [Tue Dec 13 2016 11:16:32 GMT+0100 (CET)]
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mtnB [Tue Dec 13 2016 11:16:32 GMT+0100 (CET)]

methylthioribulose-1-phosphate dehydratase
locus
BSU13610
pI
5.69
mw
23.00 kDa
function
methionine salvage
product
methylthioribulose-1-phosphate dehydratase
essential
no
ec
4.2.1.109
synonyms
ykrY

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.10|Biosynthesis/ acquisition of methionine/ S-adenosylmethionine]
  • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis/ acquisition of amino acids]
  • This gene is a member of the following [SW|regulons]

  • [SW|S-box]
  • Gene

    Coordinates on the chromosome (coding sequence)
    1,428,940 -> 1,429,569

    The protein

    Catalyzed reaction/ biological activity

  • S-methyl-5-thio-D-ribulose 1-phosphate = 5-(methylthio)-2,3-dioxopentyl phosphate + H2O (according to Swiss-Prot)
  • Protein family

  • MtnB subfamily (according to Swiss-Prot)
  • Expression and Regulation

    Operon

  • ''[protein|search|mtnW]-[protein|search|mtnX]-[protein|search|mtnB]-[protein|search|mtnD]'' [Pubmed|12022921]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|12022921]
  • Regulation

  • repressed by casamino acids [Pubmed|12107147]
  • induced by methionine starvation ([protein|search|S-box]) [Pubmed|10094622]
  • Regulatory mechanism

  • [protein|search|S-box]: transcription termination/ antitermination, the [protein|search|S-box] [SW|riboswitch] binds S-adenosylmethionine resulting in termination [Pubmed|10094622]
  • References

  • 12022921,11914366,12107147,15102328,12787499,18039762