buffering protein for development, dampens transitions to spore, biofilm exopolysaccharide and competence expression , targets ComK and ComS to ClpC-ClpP degradation machine (in log Phase), inhibits the transcriptional activity of Spo0A?P by direct interaction
function
control of ComK degradation, regulation of competence
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.7|Genetic competence][category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.7|Proteolysis] → [category|SW 3.3.7.4|Additional proteins involved in proteolysis][category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.3|Genetic competence][SW|Categories] containing this gene/protein
[SW|genetic competence], [SW|proteolysis]The protein
Protein family
mecA family (according to Swiss-Prot)Paralogous protein(s)
[protein|search|YpbH][SW|Domains]
N-terminal domain (1 ... 120): recruitment of protein substrates [Pubmed|19801546]C-terminal domain (121 ... 218): facilitates assembly of the [protein|search|ClpC]-[protein|search|ClpP] oligomer and acts as a degradation tag [Pubmed|19801546]Structure
[http://www.proteopedia.org/wiki/index.php/3jtp 3JTP] (C-terminal domain) [Pubmed|19801546][PDB|3PXG], [PDB|3J3U 3J3U] (the [protein|search|MecA]-[protein|search|ClpC] complex) [Pubmed|23595989][SW|Interactions]
[protein|search|MecA]-[protein|search|ComK] [Pubmed|10447896][protein|search|MecA]-[protein|search|ComS] [Pubmed|10447896][protein|search|ClpC]-[protein|search|MecA] [Pubmed|10447896][protein|search|MecA]-[SW|Spo0A] [Pubmed|21435029]Expression and Regulation
Operon
''[protein|search|mecA]'' [Pubmed|8412687][SW|Sigma factor]
[protein|search|SigA] [Pubmed|8412687]Biological materials
Mutant
GP813 (spc), GP814 (aphA3) both available in the [SW|Stülke] labReferences
Reviews
23375660,23479438,19609260 Original Publications
11914365,9000055,17560370,19361434,9890793,2113920,8817496,8412687,11918817,10447896,12028382,8016067,10361283,11703662,9535081,19767395,19801546,8016066,19202088,8083167,21368759,23595989,16525504,12598648,21435029